Бендамустин в лечении множественной миеломы

КЛИНИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ ЛИМФОИДНЫХ ОПУХОЛЕЙ , ,

О.М. Вотякова

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва, Российская Федерация

Для цитирования: Вотякова О.М. Бендамустин в лечении множественной миеломы. Клин. онкогематол. 2014; 7(3): 301–10.

РЕФЕРАТ

Бендамустин — противоопухолевый препарат с двойным механизмом действия, сочетающий свойства алкилирующего соединения и пуринового аналога, с многообещающей активностью при множественной миеломе (ММ). В 2013 г. в России бендамустин (Рибомустин) зарегистрирован для лечения больных старше 65 лет с впервые диагностированной ММ, не являющихся кандидатами на проведение высокодозной химиотерапии с аутологичной трансплантацией гемопоэтических стволовых клеток (ВДХТ с аутоТГСК), с клиническими проявлениями нейропатии, препятствующей использованию талидомида и бортезомиба. В обзоре приводятся данные по эффективности и безопасности применения бендамустина как в монорежиме, так и в сочетании с глюкокортикоидами и таргетными препаратами (бортезомиб, талидомид, леналидомид) у первичных больных и при рецидивах ММ. Представленные в обзоре данные позволяют рекомендовать бендамустин в сочетании с глюкокортикоидами и новыми препаратами у больных ММ с повторными рецидивами, а также в качестве терапии первой линии у отдельных первичных пациентов с полинейропатией, не являющихся кандидатами на проведение ВДХТ с аутоТГСК.

Ключевые слова: множественная миелома, бендамустин, Рибомустин.

Принято в печать: 23 мая 2014 г.

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