Современные аспекты диагностики и лечения анапластической крупноклеточной лимфомы у детей (обзор литературы)

КЛИНИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ МИЕЛОИДНЫХ ОПУХОЛЕЙ , , ,

А.С. Левашов1, Т.Т. Валиев1, А.М. Ковригина2, А.В. Попа1, Г.Л. Менткевич1

1 ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478

2 ФГБУ «Гематологический научный центр» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167

Для переписки: Андрей Сергеевич Левашов, научный сотрудник, Каширское ш., д. 24, Москва, Российская Федерация, 115478; тел.: +7(916)233-05-75; e-mail: andreyslevashov@mail.ru

Для цитирования: Левашов А.С., Валиев Т.Т., Ковригина А.М. и др. Современные аспекты диагностики и лечения анапластической крупноклеточной лимфомы у детей (обзор литературы). Клиническая онкогематология. 2016;9(2):199–207.

DOI: 10.21320/2500-2139-2016-9-2-199-207

РЕФЕРАТ

Анапластическая крупноклеточная лимфома (АККЛ) включает различные варианты заболевания, гетерогенные по клиническим, морфологическим, иммунологическим, цитогенетическим и молекулярно-биологическим параметрам. В обзоре не только приведены основные клинические и иммуноморфологические особенности АККЛ, но и представлены данные по экспрессии и прогностической роли STAT3, pSTAT3tyr705, survivin (транскрипционный фактор). Показано значение определения минимальной диссеминированной болезни (минимальная диссеминированная болезнь оценивается перед началом лечения методом ПЦР, минимальная остаточная болезнь — в процессе лечения и после его завершения), обозначены клинические и молекулярно-биологические факторы прогноза. Единой программы терапии АККЛ у детей в настоящее время нет. Однако наиболее эффективными признаются NHL-BFM 90/95, CCG5941, SFOP-LM 89/91, UKCCSG, ALCL99-Vinblastine, POG АРО 9315, AIEOP LNH-92/97. Результаты лечения по этим протоколам представлены в настоящей работе. Отдельное внимание уделяется изучению молекулярно-биологических маркеров, которые открывают путь к дальнейшему совершенствованию стратификации больных на группы риска и возможности применения таргетных препаратов (мультикиназных ингибиторов и моноклональных антител), улучшающих результаты терапии.

Ключевые слова: анапластическая крупноклеточная лимфома, диагностика, лечение, дети.

Получено: 3 февраля 2016 г.

Принято в печать: 10 февраля 2016 г.

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