Альтернативное кровоснабжение в костном мозге при онкогематологических заболеваниях

ОБЗОРЫ , ,

А.А. Вартанян

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: А.А. Вартанян, д-р биол. наук, ст. науч. сотрудник, Каширское ш., д. 24, Москва, Российская Федерация, 115478; тел.: +7(499)324-10-65; e-mail: zhivotov57@mail.ru

Для цитирования: Вартанян А.А. Альтернативное кровоснабжение в костном мозге при онкогематологических заболеваниях. Клин. онкогематол. 2014; 7(4): 491–500.

РЕФЕРАТ

Неоангиогенез, или формирование новых микрососудов на основе уже существующей в ткани сети сосудов, является необходимым условием для роста опухоли. Долгое время неоангиогенез считали единственной возможностью доставки в опухоль питательных веществ и кислорода. В последние годы рассматриваются также альтернативные механизмы васкуляризации опухоли. Формирование высокоструктурированных васкулярных каналов из опухолевых клеток в отсутствие эндотелиальных клеток и фибробластов, ограниченных базальной мембраной, или васкулогенная мимикрия (ВМ), сегодня рассматривается как дополнительная система кровоснабжения опухоли. ВМ обнаружена практически во всех опухолях, и ее появление ассоциируется с плохим прогнозом. В настоящем обзоре суммированы основные характеристики ВМ в солидных опухолях и при онкогематологических заболеваниях. Обсуждается также значение указанного феномена в диагностике опухолей и в прогнозировании их течения.

Ключевые слова: неоангиогенез, васкулогенная мимикрия, онкогематологические заболевания.

Принято в печать: 1 сентября 2014 г.

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