Хронический лимфолейкоз высокого риска: история, определение, диагностика и лечениеХронический лимфолейкоз высокого риска: история, определение, диагностика и лечение

КЛИНИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ ЛИМФОИДНЫХ ОПУХОЛЕЙ , , ,

Е.А. Никитин, А.Б. Судариков

Федеральное государственное бюджетное учреждение «Гематологический научный центр Министерства здравоохранения Российской Федерации», Москва, Российская Федерация

РЕФЕРАТ

Хронический лимфолейкоз высокого риска – новое и все более уточняемое понятие, которое появилось в эру флударабина. Клиническое значение ХЛЛ высокого риска объясняется очень плохим прогнозом по сравнению с остальной группой пациентов. В статье представлен краткий исторический обзор, а также современное определение этого понятия, рассматриваются молекулярные механизмы, лежащие в основе ХЛЛ высокого риска, а также подходы к терапии.

Ключевые слова: хронический лимфолейкоз, TP53, делеция 17p, флударабин.

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