Лечение распространенных стадий лимфомы Ходжкина: обзор литературы

ОБЗОРЫ , , , ,

А.А. Леонтьева, Е.А. Демина

ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: Анна Александровна Леонтьева, аспирант, Каширское ш., д. 24, Москва, Российская Федерация, 115478; тел.: +7(499)324-90-89; e-mail: aurevoir-nut@yandex.ru

Для цитирования: Леонтьева А.А., Демина Е.А. Лечение распространенных стадий лимфомы Ходжкина: обзор литературы. Клиническая онкогематология. 2015;8(3):255–66.

РЕФЕРАТ

В последнее десятилетие крупные исследовательские центры в Европе и США, имеющие большие базы данных, провели комплексный анализ эффективности лечебных программ, поздних осложнений терапии и показателей длительной выживаемости больных с распространенными стадиями лимфомы Ходжкина. Этот анализ позволил разработать и предложить практической медицине новые программы, отличающиеся большей эффективностью, и начать поиск менее токсичных вариантов лечения. Однако в отечественной литературе такой комплексный анализ не представлен. Имеющиеся публикации и научные исследования освещают лишь отдельные аспекты диагностики и лечения лимфомы Ходжкина, или в них выборочно обсуждаются проблемы осложнений. Предлагаемый обзор позволяет читателю проследить путь, пройденный в лечении распространенных стадий лимфомы Ходжкина за 75 лет — от абсолютно пессимистического прогноза до современных высоких результатов с дальнейшим совершенствованием терапии этой злокачественной опухоли.

Ключевые слова: лимфома Ходжкина, распространенные стадии, лечение, эффективность, токсичность.

Получено: 20 февраля 2015 г.

Принято в печать: 28 мая 2015 г.

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