Роль экспрессии c-MYC, BCL2 и BCL6 в патогенезе диффузной В-крупноклеточной лимфомы

ОБЗОРЫ

А.Е. Мисюрина1, В.А. Мисюрин2, Е.А. Барях1, А.М. Ковригина1, С.К. Кравченко1

1 ФГБУ «Гематологический научный центр» МЗ РФ, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167

2 ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: А.Е. Мисюрина, аспирант, Новый Зыковский проезд, д. 4а, Москва, Российская Федерация, 125167; тел.: +7(909)637-32-49; e-mail: anna.lukina1@gmail.com

Для цитирования: Мисюрина А.Е., Мисюрин В.А., Барях Е.А., Ковригина А.М., Кравченко С.К. Роль экспрессии генов c-MYC, BCL2 и BCL6 в патогенезе диффузной В-крупноклеточной лимфомы. Клин. онкогематол. 2014; 7(4): 512–521.

РЕФЕРАТ

Согласно современным представлениям, опирающимся на результаты исследования профиля экспрессии генов, существует несколько подтипов диффузной B-крупноклеточной лимфомы (ДBКЛ): из В-клеток герминативного центра и из активированных В-клеток. Гены c-MYC, BCL6 и BCL2 являются ключевыми регуляторами развития В-лимфоцитов на уровне герминальной (фолликулярной) дифференцировки. В патогенезе ДВКЛ наиболее часто играют роль генетические аномалии с их участием. От общего уровня активности и механизмов, приводящих к гиперэкспрессии каждого из этих генов и продукции соответствующих белков, зависит прогноз заболевания. Мы предполагаем, что определение количественных параметров экспрессии генов c-MYC, BCL6 и BCL2, а также кодируемых ими белков позволит с высокой точностью выделять группы риска среди больных ДBКЛ.

Ключевые слова: диффузная В-крупноклеточная лимфома, молекулярные подтипы, группы риска, c-MYC, BCL6, BCL2.

Принято в печать: 8 сентября 2014 г.

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