элотузумаб

Элотузумаб в лечении множественной миеломы (обзор литературы)

ЛИМФОИДНЫЕ ОПУХОЛИ , , ,

О.М. Вотякова

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: Ольга Михайловна Вотякова, канд. мед. наук, Каширское ш., д. 24, Москва, Российская Федерация, 115478; тел.: +7(499)324-92-09; e-mail: omvtk@yandex.ru

Для цитирования: Вотякова О.М. Элотузумаб в лечении множественной миеломы (обзор литературы). Клиническая онкогематология. 2016;9(4):438–45.

DOI: 10.21320/2500-2139-2016-9-4-438-445

РЕФЕРАТ

Основным методом лечения множественной миеломы на протяжении десятилетий была химиотерапия. Однако значительное увеличение продолжительности жизни больных отмечено после внедрения в клиническую практику талидомида, бортезомиба и леналидомида. Тем не менее болезнь остается неизлечимой и необходима разработка принципиально новых лечебных подходов. Элотузумаб — это гуманизированное моноклональное антитело IgG1, специфической мишенью которого является антиген SLAMF7. Он относится к семейству сигнальных молекул, активирующих лимфоциты. Высокая экспрессия этого антигена выявляется на миеломных клетках. В обзоре представлены механизм действия элотузумаба, доклинические данные и основные клинические исследования.

Ключевые слова: моноклональные антитела, элотузумаб, клинические исследования, множественная миелома.

Получено: 25 мая 2016 г.

Принято в печать: 15 июня 2016 г.

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