пироптоз

Пироптоз — воспалительная форма клеточной гибели

ОБЗОРЫ , , ,

А.А. Вартанян, В.С. Косоруков

ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: Aмалия Арташевна Вартанян, д-р биол. наук, ул. Каширская, д. 24, Москва, Российская Федерация, 115478; тел.: +7(499)324-10-65; e-mail: zhivotov57@mail.ru

Для цитирования: Вартанян А.А., Косоруков В.С. Пироптоз — воспалительная форма клеточной гибели. Клиническая онкогематология. 2020;13(2):129–35.

DOI: 10.21320/2500-2139-2020-13-2-129-135

РЕФЕРАТ

Пироптоз, каспаза-1-зависимая воспалительная форма гибели клетки, индуцируется внутриклеточными патогенами или повреждением тканей. Активация прокаспазы-1, необходимая для процессинга провоспалительных цитокинов про-IL-1β и про-IL-18, происходит в макромолекулярных белковых комплексах, называемых инфламмасомами. При инфекциях, вызванных грамотрицательными бактериями, в сборке инфламмасомы участвует каспаза-4 и каспаза-5. Первоначально идентифицированный как защитный механизм врожденного иммунитета, пироптоз сегодня не ограничивается ингибированием размножения внутриклеточных патогенов. В данном обзоре обсуждаются молекулярные механизмы гибели клетки по типу пироптоза и возможности вовлечения пироптоза в гибель опухолевых клеток.

Ключевые слова: клеточная гибель, пироптоз, каспазы, воспаление, врожденный иммунитет.

Получено: 24 декабря 2019 г.

Принято в печать: 17 марта 2020 г.

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