Цитогенетические и молекулярно-генетические факторы прогноза острых лимфобластных лейкозов

ОБЗОРЫ , , , ,

А.В. Мисюрин

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: Андрей Витальевич Мисюрин, канд. биол. наук, Каширское ш., д. 24, Moсква, Российская Федерация, 115478; e-mail: and@genetechnology.ru

Для цитирования: Мисюрин А.В. Цитогенетические и молекулярно-генетические факторы прогноза острых лимфобластных лейкозов. Клиническая онкогематология. 2017;10(3):317–23.

DOI: 10.21320/2500-2139-2017-10-3-317-323

РЕФЕРАТ

В обзоре представлены характерные и воспроизводимые при острых лимфобластных лейкозах (ОЛЛ) перестройки хромосом, которые можно обнаружить при стандартном цитогенетическом исследовании (окраска на G-полосы) или методом FISH. Более тонкие генетические изменения, недоступные для наблюдения цитогенетиков, выявляются с помощью современных методов молекулярно-биологической диагностики. Показано прогностическое значение цитогенетических и молекулярно-генетических маркеров ОЛЛ. Представлен минимальный набор клинически значимых молекулярных маркеров, которые целесообразно исследовать при ОЛЛ.

Ключевые слова: острый лимфобластный лейкоз, хромосомная аномалия, химерный онкоген, экспрессия гена, мутация гена.

Получено: 3 декабря 2016 г.

Принято в печать: 8 марта 2017 г.

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