Применение ритуксимаба у гематологических больных с ВИЧ-инфекцией

МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА И ВИЧ-ИНФЕКЦИЯ , , , ,

А.В. Пивник

Медицинский центр «Генотехнология», Москва, Российская Федерация

РЕФЕРАТ

Ритуксимаб (Мабтера) – один из мощных лекарственных препаратов, избирательно действующий на В-клетки. В случаях аутоиммунных заболеваний,  препарат супрессирует поликлональный ответ антителами на собственные антигены. При лимфатических опухолях он избирательно действует на опухолевые В-клетки. Ритуксимаб широко используется для лечения ряда аутоиммунных заболеваний и лимфатических опухолей. Показано успешное применение препарата у больных иммунной тромбоцитопенической пурпурой (ИТП), тромботической тромбоцитопенической пурпурой Мошковица (ТТП), аутоиммунной гемолитической анемией (АИГА), ревматоидным артритом (РА), системной красной волчанкой (СКВ), болезнью Крона и другими заболеваниями. В обзоре приведены описания клинических наблюдений у больных с перечисленными заболеваниями. Все пациенты инфицированы ВИЧ на разных стадиях течения заболевания. Показана эффективность применения препарата и умеренная его токсичность. Основные показатели ВИЧ-инфекции (уровень CD4 и вирусная нагрузка) не зависели от применения препарата. В целом, показана положительная оценка использования ритуксимаба у ВИЧ-инфицированных пациетов.

Ключевые слова: ритуксимаб и ВИЧ-инфекция, ИТП, АИГА, ТТП, лимфомы у ВИЧ-инфицированных больных.

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