Association between HLA-DRB1 alleles and response to imatinib in chronic myeloid leukemia

LYMPHOID TUMORS ,

E.G. Ovsyannikova1, I.L. Davydkin2, E.A. Popov1, L.V. Zaklyakova1, and B.N. Levitan1

1 Astrakhan State Medical Academy, RF Ministry of Health, Astrakhan, Russian Federation

2 Research Institute of Hematology, Transfusiology, and Intensive Care, Samara State Medical University, RF Ministry of Health, Samara, Russian Federation

ABSTRACT

The article presents analysis of association between the HLA-DRB1 gene alleles and the response to imatinib in the patients with Ph-positive chronic myeloid leukemia (Ph+ CML). HLA class II alleles, DRB1 locus, were determined using PCR-SSP. The predictors of optimal response to imatinib in 3 to 18-months treatment of CML are HLA-DRB1*16(02), HLA-DRB1*17(03), and HLA-DRB1*08 specificities. Immunogenetic markers of imatinib treatment failure are HLA-DRB1*11(05), HLA-DRB1*12(05), and HLA-DRB1*14(06) alleles. The results obtained can be used for the development of individual long-term prognosis for chronic myeloid leukemia and optimization of the treatment choice.

Keywords: chronic myeloid leukemia, HLA-DRB1, imatinib, prognosis.

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