Cardiovascular Complications of the Immunotherapy of Hematological Malignancies: A Literature Review

AUTOIMMUNE THROMBOCYTOPENIA

GR Gimatdinova1, OE Danilova2, VP Kuzmin1, GI Davydkin1, YuV Kostalanova3, DA Kudlai4, IL Davydkin2

1 Samara State Medical University, 89 Chapaevskaya ul., Samara, Russian Federation, 443099

2 SamGMU Research Institute of Hematology, Transfusiology and Intensive Care, 165Б K. Marksa pr-t, Samara, Russian Federation, 443086

3 Samara Regional Clinical Oncology Dispensary, 50 Solnechnaya ul., Samara, Russian Federation, 443031

4 NRC Institute of Immunology FMBA of Russia, 24 Kashirskoye sh., Moscow, Russian Federation, 115522

For correspondence: Geliya Rifkatovna Gimatdinova, 89 Chapaevskaya ul., Samara, Russian Federation, 443099; Tel.: +7(919)809-68-56; e-mail: gimatdinova1995@icloud.com

For citation: Gimatdinova GR, Danilova OE, Kuzmin VP, et al. Cardiovascular Complications of the Immunotherapy of Hematological Malignancies: A Literature Review. Clinical oncohematology. 2023;16(4):407–12. (In Russ).

DOI: 10.21320/2500-2139-2023-16-4-407-412

ABSTRACT

In clinical oncology in general, tumor treatment is closely related to a highly relevant issue of chemotherapy-induced adverse events. Among side effects, cardiovascular toxicity occupies the foremost place. The strategy of controlling the cardiovascular complications associated with antitumor drug and cell therapies presupposes an early diagnosis of changes in the heart muscle and blood vessels at the stage of subclinical manifestations of adverse events. The present literature review provides the analysis of data on immunotherapy side effects in hematological malignancies with a focus on cardiovascular complications. The review comprehensively discusses the characteristics of cardiovascular complications associated with immune checkpoint inhibitors, CAR-T cell products, bispecific antibodies as well as immunomodulatory and antiangiogenic drugs.

Keywords: cardiotoxicity, immunotherapy, oncology, hematology.

Received: April 3, 2023

Accepted: September 30, 2023

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Статистика Plumx английский

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