CAR-Т Cells for the Treatment of Chronic Lymphocytic Leukemia: Literature Review

AUTOIMMUNE THROMBOCYTOPENIA

IV Gribkova, AA Zav’yalov

Research Institute of Healthcare and Medical Management, 9 Sharikopodshipnikovskaya str., Moscow, Russian Federation, 115088

For correspondence: Irina Vladimirovna Gribkova, PhD in Biology, 9 Sharikopodshipnikovskaya str., Moscow, Russian Federation, 115088; Tel.: +7(916)078-73-90; e-mail: igribkova@yandex.ru

For citation: Gribkova IV, Zav’yalov AA. CAR-Т Cells for the Treatment of Chronic Lymphocytic Leukemia: Literature Review. Clinical oncohematology. 2021;14(2):225–30. (In Russ).

DOI: 10.21320/2500-2139-2021-14-2-225-230

ABSTRACT

Chronic lymphocytic leukemia (CLL) is the most common adult malignant lymphoid disease. Despite new highly effective targeted drugs, the prognosis of relapsed and resistant form of this disease is poor. CAR-Т cell therapy using T-lymphocytes with chimeric antigen receptor (CAR) demonstrated its efficacy in the treatment of such oncohematological diseases as В-cell non-Hodgkin’s lymphomas and acute lymphoblastic leukemia. The present literature review focuses on the experience of using CAR-Т cells for CLL therapy. It presents the advantages and drawbacks of this technique as well as the challenging issues to be solved for its implementation into broad clinical practice.

Keywords: chronic lymphocytic leukemia, CAR-Т cell therapy, chimeric antigen receptor, adoptive therapy, immunotherapy.

Received: December 15, 2020

Accepted: March 10, 2021

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Статистика Plumx английский

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