EXPERIMENTAL STUDIES

Evolution of concepts for diagnosis and treatment of Burkitt’s lymphoma

EXPERIMENTAL STUDIES , , ,

T.T. Valiev1 and E.A. Baryakh2

1 Pediatric Oncology and Hematology Institute, N.N. Blokhin Russian Cancer Research Center, RAMS, Moscow, Russian Federation

2 Hematology Research Center, RF MH, Moscow, Russian Federation

ABSTRACT

The issues of diagnosis and treatment of the most aggressive lymphoid tumor, namely, Burkitt’s lymphoma (BL), are presented in the historical context. The clinical and laboratory features of endemic and sporadic BL variants are described. Possible mechanisms of Epstein-Barr virus and Plasmodium falciparum involvement in BL pathogenesis are suggested. Also, the morphologic, immunologic and cytogenetic BL diagnostic criteria are described. Based on molecular and genetic features, the issues of differential diagnosis with the heterogeneous group of diffuse large B-cell and highly aggressive mature B-cell lymphomas with additional proto-oncogene aberrations («double» and «triple» hit lymphomas) are presented. BL therapy and the role of rituximab in it is emphasized.

Keywords: Burkitt’s lymphoma, clinical presentation, diagnosis, treatment.

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Factors determining in vitro survival of human multiple myeloma cells

EXPERIMENTAL STUDIES , , ,

S.S. Shushanov1, T.A. Kravtsova1, and Yu.B. Cherhykh2

1 N.N. Blokhin Russian Cancer Research Center, RAMS, Moscow, Russian Federation

2 M.F. Vladimirskiy Moscow Regional Research-and-Clinical Institute, Moscow, Russian Federation

ABSTRACT

In this work, we investigated the survival of the human MM cell lines, i.e. RPMI1640, RPMI8226, and IM9, depending on the degree of their differentiation and impact of exogenous IGF-1. The study showed that the most and least sensitive to growth factors are IM9 cells with CD138+, CD38–, CD45+, CD56–, or CD19+ immunophenotype and RPMI1640 and RPMI8226 cells with (CD138+, CD38+, CD45–, CD56+/–, or CD19– immunophenotype, respectively The gene expression studies revealed that the level of IGF-1R and IRA mRNA expression was significantly lower in the IM9 cells than in the RPMI1640 or RPMI8226 cells. Also, we established that exogenous IGF-1 could variously influence the survival and growth of MM cells. IGF-1 alone exerts no effect on the myeloma cell viability, but, in combination with serum growth factors, it increases the parameter.

Keywords: multiple myeloma (MM), insulin-like growth factor 1 (IGF-1), cell survival, mRNA expression.

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REFERENCES

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In vitro model of myelofibrosis using human platelet lysate

EXPERIMENTAL STUDIES , , ,

Ye.N. Bulycheva, N.T. Siordiya, E.G. Lomaia, A.Yu. Zaritskiy, and P.A. Butylin

V.A. Almazov Federal Heart, Blood and Endocrinology Center, Saint Petersburg, Russian Federation

ABSTRACT

The development and studies of the myelofibrosis (MF) in vitro model is an important issue, since such model can lead to understanding of pathogenesis and identifying the new targets for therapy.

Objectives. Here, we studied the properties of mesenchymal stromal cells (MSCs) cultured in the medium containing the human platelet lysate (HPL).

Design and methods. Bone marrow MSCs from healthy donors and a patient with primary myelofibrosis (PMF) were cultured in the media containing various HPL concentrations. We measured the proliferative activity, the collagen type I and III expression, and capability to differentiate into the osteogenic or adipogenic lineages. The concentrations of the vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor beta (TGF-b), and hepatocyte growth factor (HGF) were measured in HPL from 17 patients with primary myelofibrosis or post-polycythemia vera myelofibrosis (post-PV MF) using the specific ELISA kits.

Results. The highest MSC proliferative rate was found in the cultures with high HPL concentrations (10–20 %). The ratio of collagen type III/collagen type I expression was the highest in the cultures containing 10 % HPL. The use of HPL for MSCs culturing caused no changes in their osteogenic differentiation capability, but the increase in the HPL concentration resulted in the decreased capability to differentiate into the adipogenic lineage. Further, we observed the significantly increased VEGF and bFGF concentrations in HPL from MF patients, compared to the age-matched healthy controls (2.5- and 2.4-fold, respectively, p < 0.01), while the TGF-b and HGF concentrations showed the trend towards an increase, but with no significant difference from the controls. MSCs cultured with HPL from MF patients showed a higher proliferative rate compared to HPL from healthy donors. MSCs from the PMF patient tended to proliferate more actively compared to the cells from healthy donors.

Conclusion. MSCs culturing using varying HPL concentrations can be used as an adequate MF in vitro model, since it leads to pro-fibrotic changes in the bone marrow stromal cells.

Keywords: primary myelofibrosis, platelet lysate, mesenchymal stromal cells, myelofibrosis in vitro model.

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