Current therapies for AL amyloidosis: literature review and our data

LYMPHOID TUMORS , , ,

A.G. Smirnova1, S.N. Bondarenko1, A.A. Kisina2, A.V. Smirnov2, A. Tsander 3, and B.V. Afanasyev1

1 R.M. Gorbacheva Institute of Pediatric Hematology and Transplantology, I.P. Pavlov State Medical University, Saint Petersburg, Russian Federation

2 Research Institute of Nephrology, I.P. Pavlov State Medical University, Saint Petersburg, Russian Federation

3 Universitare Transplantations-Centrum, Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany

ABSTRACT

AL amyloidosis is a relatively rare condition belonging to plasma cell dyscrasias with very heterogeneous clinical presentation and poor prognosis. This article presents a brief description of AL amyloidosis, current therapies, and our own statistics on new combination therapy outcomes. We included 46 patients with confirmed AL amyloidosis who received autologous stem cell transplantation and standard combination chemotherapy, including melphalan + dexamethasone or bortezomib + dexamethasone.

Keywords: AL amyloidosis, therapy, hematopoietic stem cell transplantation, melphalan, bortezomib.

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