Gynecological Myeloid Sarcoma: Literature Review and a Case Report

AUTOIMMUNE THROMBOCYTOPENIA

AA Shatilova1, LL Girshova1, DV Zaitsev1, IG Budaeva1, YuV Mirolyubova1, DV Ryzhkova1, RV Grozov1, KV Bogdanov1, TS Nikulina1, DV Motorin1, DB Zammoeva1, SV Efremova1, VV Ivanov1, AV Petukhov1,2, YuA Alekseeva1, AYu Zaritskey1

1 VA Almazov National Medical Research Center, 2 Akkuratova str., Saint Petersburg, Russian Federation, 197341

2 Institute of Cytology, 4 Tikhoretskii pr-t, Saint Petersburg, Russian Federation, 194064

For correspondence: Aleksina Alekseevna Shatilova, 2 Akkuratova str., Saint Petersburg, Russian Federation, 197341; Tel.: +7(911)476-35-58; e-mail: alexina-96@list.ru

For citation: Shatilova AA, Girshova LL, Zaitsev DV, et al. Gynecological Myeloid Sarcoma: Literature Review and a Case Report. Clinical oncohematology. 2021;14(1):31–44. (In Russ).

DOI: 10.21320/2500-2139-2021-14-1-31-44

ABSTRACT

Myeloid sarcoma, also known as chloroma or granulocytic sarcoma, is a rare disease characterized by the proliferation of immature myeloid cells in extramedullary lesions. Chloroma is more commonly observed in patients with acute myeloid leukemias, other myeloproliferative neoplasms, or myelodysplastic syndrome. However, it can also manifest itself as solitary tumor. Sarcoma can develop in different organs and tissues, but most frequently it appears in lymph nodes, soft tissues, and bones. Myeloid sarcoma with primary gynecological lesion is very rarely mentioned. In literature cases of cervical lesions are described. The present article summarizes the literature data concerning different aspects of myeloid sarcoma diagnosis and treatment. The issue under discussion is the role of chemotherapy, radiotherapy, surgery, and bone marrow transplantation in the treatment of this malignant tumor. It appears that whatever the primary tumor localization, the best treatment options are chemotherapy and allogeneic bone marrow transplantation (allo-BMT). A promising trend is the use of novel targeted drugs improving outcomes of treatment. The article provides a case report of a female patient with cervical myeloid sarcoma and concomitant bone marrow involvement, as well as the description of clinical course, diagnosis, and treatment. The patient received chemotherapy with subsequent allo-BMT. The pre-transplant therapy enabled allo-BMT with the deepest response possible. The patient achieved PET- and MRD-negative complete remission of cervical myeloid sarcoma and bone marrow.

Keywords: cervical myeloid sarcoma, gynecologic tract, acute myeloid leukemias.

Received: August 12, 2020

Accepted: December 4, 2020

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