Langerhans Cell Histiocytosis in Adults: Treatment Opportunities of Today

AUTOIMMUNE THROMBOCYTOPENIA

VD Latyshev, EA Lukina

National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

For correspondence: Vitalii Dmitrievich Latyshev, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; e-mail: LatyshevVD@gmail.com

For citation: Latyshev VD, Lukina EA. Langerhans Cell Histiocytosis in Adults: Treatment Opportunities of Today. Clinical oncohematology. 2021;14(4):444–54. (In Russ).

DOI: 10.21320/2500-2139-2021-14-4-444-454

ABSTRACT

Langerhans cell histiocytosis (LCH) is an extremely rare disease associated with tissue infiltration by pathological cells which are phenotypically similar to normal Langerhans cells. Standard therapy of LCH in adults has not been developed so far, due to the lack of sufficient evidence base for different treatment methods. In clinical practice, cytostatic treatment is applied along with new approaches using signaling pathway inhibitors involved in LCH pathogenesis. This literature review covers currently existing methods of LCH therapy in adults and their feasibility in clinical practice.

Keywords: Langerhans cell histiocytosis, treatment of histiocytosis, BRAFV600E mutation, MAPK.

Received: July 20, 2021

Accepted: September 23, 2021

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Статистика Plumx английский

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