Materials of the II Conference “Current Issues of Diagnosis and Treatment of Ph-Negative and Ph-Positive Myeloproliferative Neoplasms” (March 15–16, 2019; National Research Center for Hematology, Moscow)

AUTOIMMUNE THROMBOCYTOPENIA

AL Melikyan1, AG Turkina1, IN Subortseva1, EYu Chelysheva1, AM Kovrigina1, VA Shuvaev2, VV Baikov3, OYu Vinogradova4,5,6, SM Kulikov1, AN Petrova1, AV Bykova1, A-PA Poshivai2, YuYu Vlasova3, MM Chukavina7, OD Serdyuk8, KV Naumova9, NT Siordiya10, NS Lazorko10, RV Grozov10, EI Mullo11, AS Maksimova12, OM Senderova13, OV Kanya13, MS Fominykh2,25, DI Shikhbabaeva4, EA Belyakova14, IS Martynkevich2, LB Polushkina2, MN Zenina2, EV Efremova2, VI Rugal2, LP Papayan2, NE Korsakova2, OYu Matvienko2, EB Syrtseva15, SV Gappoev16, MV Barabanshchikova3, MO Ivanova3, KD Kaplanov17, ES Rogova9, KB Trizna18, AS Zhevnyak19, OE Ochirova20, AA Shakhaeva20, AS Lyamkina21, IP Mikhno22, YuB Chernykh23, TV Chudanova23, IN Kontievskii23, NN Glonina24, MV Burundukova22

1 National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

2 Russian Research Institute of Hematology and Transfusiology, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024

3 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022

4 SP Botkin Municipal Clinical Hospital, 5 2-i Botkinskii pr-d, Moscow, Russian Federation, 125284

5 Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela str., Moscow, Russian Federation, 117997

6 NI Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, Russian Federation, 117997

7 Kolomenskaya Central Regional Hospital, 318 Oktyabrskoi revolyutsii str., Kolomna, Moscow Region, Russian Federation, 140401

8 Clinical Oncology Dispensary No. 1, 146 Dimitrova str., Krasnodar, Russian Federation, 350040

9 Samara State Medical University, 165b Karla Marksa pr-t, Samara, Russian Federation, 443086

10 VA Almazov National Medical Research Center, 2 Akkuratova str., Saint Petersburg, Russian Federation, 197341

11 Chekhov Regional Hospital No. 2, 37 Gagarina str., Chekhov, Moscow Region, Russian Federation, 142300

12 Municipal Clinical Hospital No. 16, 121 Gagarina str., Kazan, Russian Federation, 420039

13 Irkutsk Regional Clinical Hospital, 100 Yubileinyi microdistrict, Irkutsk, Russian Federation, 664049

14 II Mechnikov North-Western State Medical University, 41 Kirochnaya str., Saint Petersburg, Russian Federation, 191015

15 Krasnoyarsk Interdistrict Municipal Hospital No. 7, 4 Akademika Pavlova str., Krasnoyarsk, Russian Federation, 660003

16 Krasnoyarsk Pathology Bureau, 3d Partizana Zheleznyaka str., Krasnoyarsk, Russian Federation, 660022

17 Volgograd Regional Clinical Oncology Dispensary No. 1, 78 Zemlyachki str., Volgograd, Russian Federation, 400138

18 Tomsk Regional Clinical Hospital, 96 Ivana Chernykh str., Tomsk, Russian Federation, 634063

19 Pathology Bureau, 96 Ivana Chernykh str., Tomsk, Russian Federation, 634063

20 NA Semashko Republican Clinical Hospital, 12 Pavlova str., Ulan-Ude, Russian Federation, 670031

21 Novosibirsk State Medical University, 52 Krasnyi pr-t, Novosibirsk, Russian Federation, 630091

22 Municipal Clinical Hospital No. 2, 21 Polzunova str., Novosibirsk, Russian Federation, 630051

23 NF Vladimirskii Moscow Regional Research Clinical Institute, 61/2 Shchepkina str., Moscow, Russian Federation, 129110

24 SI Sergeev Clinical Hospital No. 1, 9 Krasnodarskaya str., Khabarovsk, Russian Federation, 680009

25 Saint Petersburg State University, 7-9 Universitetskaya nab., Saint Petersburg, Russian Federation, 199034

For correspondence: Irina Nikolaevna Subortseva, MD, PhD, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; e-mail: soubortseva@yandex.ru

For citation: Melikyan AL, Turkina AG, Subortseva IN, et al. Materials of the II Conference “Current Issues of Diagnosis and Treatment of Ph-Negative and Ph-Positive Myeloproliferative Neoplasms” (March 15–16, 2019; National Research Center for Hematology, Moscow). Clinical oncohematology. 2020;13(2):199–231 (In Russ).

ABSTRACT

The publication contains materials of the reports presented at the II Conference “Current Issues of Diagnosis and Treatment of Ph-Negative and Ph-Positive Myeloproliferative Neoplasms” held from 15 to 16 March 2019 at the National Research Center for Hematology (Moscow). The conference was organized to enable professional communication of the clinicians specializing in the treatment of myeloproliferative neoplasms (MPN), and the researchers in the related fields as well as to allow the exchange of views on the implementation of current diagnosis and treatment methods in Ph-negative and Ph-positive MPNs. Reports covered a wide range of rare and non-standard settings. Of particular importance was the opportunity to debate them in detail at panel discussions and interactive sessions. This format of the conference allowed to provide expert opinions in the present publication. It emphasizes the importance of complex diagnosis in MPN using morphological examination of bone marrow core biopsy samples and molecular genetic testing. Accordingly, the second day of the conference was devoted to a thorough analysis of the morphological characteristics of the cases presented and based on bone marrow core biopsy samples.

Keywords: myeloproliferative neoplasms, chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, primary myelofibrosis, thrombosis, JAK2V617F, CALR, MPL, next-generation sequencing, ruxolitinib.

Received: September 30, 2019

Accepted: March 5, 2020

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