Pyroptosis as Inflammatory Cell Death

AUTOIMMUNE THROMBOCYTOPENIA

AA Vartanyan, VS Kosorukov

NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Amaliya Artashevna Vartanyan, PhD in Biology, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel.: +7(499)324-10-65; e-mail: zhivotov57@mail.ru

For citation: Vartanyan AA, Kosorukov VS. Pyroptosis as Inflammatory Cell Death. Clinical oncohematology. 2020;13(2):129–35 (In Russ).

DOI: 10.21320/2500-2139-2020-13-2-129-135

ABSTRACT

Pyroptosis, caspase-1-dependent inflammatory cell death, is induced by intracellular pathogens or tissue lesions. Procaspase-1 activation, which is essential for the processing of proinflammatory cytokines pro-IL-1β and pro-IL-18, occurs in macromolecular protein complexes, also referred to as inflammasomes. In the gram-negative bacilli-induced infections inflammasome assembly incorporates caspase-4 and caspase-5. Originally identified as a protective mechanism of innate immunity, at present pyroptosis is not limited to the inhibition of intracellular pathogen multiplication. The current review discusses molecular mechanisms of pyroptosis-like cell death and possible pyroptosis involvement in tumor cell death.

Keywords: cell death, pyroptosis, caspases, inflammation, innate immunity.

Received: December 24, 2019

Accepted: March 17, 2020

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