ALK+ ALCL

Intermediate Results of Prospective, Randomized, Comparative Study of NHL BFM-90 and СНОЕР Efficacy in Primary ALK-Positive Anaplastic Large-Cell Lymphoma

AUTOIMMUNE THROMBOCYTOPENIA ,

LG Gorenkova1, SK Kravchenko1, EE Klebanova1, AM Kovrigina1, KA Sychevskaya1, EG Gemdzhian1, ES Nesterova1, YaK Mangasarova1, AU Magomedova1, AV Misyurin2, YuV Sidorova1, TN Obukhova1

1 National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

2 NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Liliya Gamilevna Gorenkova, MD, PhD, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; e-mail: l.aitova@mail.ru

For citation: Gorenkova LG, Kravchenko SK, Klebanova EE, et al. Intermediate Results of Prospective, Randomized, Comparative Study of NHL BFM-90 and СНОЕР Efficacy in Primary ALK-Positive Anaplastic Large-Cell Lymphoma. Clinical oncohematology. 2020;13(4):382–8. (In Russ).

DOI: 10.21320/2500-2139-2020-13-4-382-388

ABSTRACT

Aim. To compare NHL BFM-90 and CHOEP efficacy in adult patients with ALK-positive anaplastic large-cell lymphoma (ALK+ ALCL).

Materials & Methods. Within the period from June 2014 to December 2019 the prospective randomized comparative study at the National Research Center for Hematology in Moscow included 23 ALK+ ALCL patients. In one study arm (n = 11) CHOEP was administered, whereas the other one (n = 12) received high-dose chemotherapy (CT) according to NHL BFM-90 protocol. The median age of patients in both arms was 33 and 40 years, respectively.

Results. Overall survival (OS) and event-free survival (EFS) within 3 years were 91 % in the arm receiving CHOEP (this protocol was administered to all 11 patients), and 100 % in the arm receiving NHL BFM-90 (complete remission was achieved in all patients). Due to its toxicity NHL BFM-90 was fully implemented in 9 out of 12 patients. The 3-year OS and EFS in the CHOEP and NHL BFM-90 arms are comparable, and the difference between them is not significant.

Conclusion. In ALK+ ALCL treatment high-dose CT according to NHL BFM-90 protocol has no advantage in terms of the 3-year OS and EFS compared to less toxic regimen CHOEP. A larger sample of patients is required to achieve significant results, which will further lead to a final judgement on feasibility of high-dose regimens in the treatment of adult patients with ALK+ ALCL.

Keywords: ALK-positive anaplastic large-cell lymphoma, ALK+ ALCL, treatment, adults, CHOEP, NHL BFM-90, survival.

Received: April 8, 2020

Accepted: August 30, 2020

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