catumaxomab

Bispecific Antibodies in Clinical Practice and Clinical Trials (Literature Review)

REVIEWS , , ,

ON Solopova, VA Misyurin

NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Vsevolod Andreevich Misyurin, PhD in Biology, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel.: +7(985)436-30-19; e-mail: vsevolod.misyurin@gmail.com

For citation: Solopova ON, Misyurin VA. Bispecific Antibodies in Clinical Practice and Clinical Trials (Literature Review). Clinical oncohematology. 2019;12(2):125–44.

DOI: 10.21320/2500-2139-2019-12-2-125-144

ABSTRACT

Therapeutic monoclonal antibodies have long been an effective tool deployed by physicians of different specialties, particularly by oncologists. Bispecific antibodies opened up new horizons in the treatment of cancer as they allow to involve a patient’s endogenous immunity in his or her fight against tumor. The present review covers all the formats and strategies used in engineering of bispecific antibodies which reached the stage of clinical trials and also focuses on the available results of these clinical trials.

Keywords: bispecific antibodies, blinatumomab, catumaxomab, emicizumab, clinical trial.

Received: August 13, 2018

Accepted: January 22, 2019

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