leukemia

Clinical Significance of the PRAME Gene Expression in Oncohematological Diseases

REVIEWS , , ,

VA Misyurin

NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Vsevolod Andreevich Misyurin, PhD, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel.: +7(985)436-30-19; e-mail: vsevolod.misyurin@gmail.com

For citation: Misyurin AV. Clinical Significance of the PRAME Gene Expression in Oncohematological Diseases. Clinical oncohematology. 2018;11(1):26–33.

DOI: 10.21320/2500-2139-2018-11-1-26-33

ABSTRACT

Although the PRAME activity was first discovered in solid tumors, this gene is very frequently expressed in oncohematological diseases. PRAME can be regarded as a reliable biomarker of tumor cells. Determination of PRAME transcripts is used in residual disease monitoring and molecular relapse diagnostics. Experimentation with PRAME expressing lines of leukemia cells yielded controversial results. Therefore, it is hardly possible to estimate the prognostic value of PRAME activity in oncohematological diseases. In chronic myeloproliferative disease and chronic myeloid leukemia, however, PRAME activity proves to be a predictor of negative prognosis, and on the contrary, it can be regarded as a positive prognostic factor in acute myeloid or lymphoid leukemia. Despite many clinical studies prognostic value of PRAME expression in some diseases requires further investigation. The present literature review contains the data concerning PRAME expression in oncohematological diseases.

Keywords: PRAME, leukemia, lymphoma, prognosis.

Received: September 14, 2017

Accepted: December 2, 2017

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Surgical Treatment of Perianal Infectious Complications in Hematologic Clinic

SURGICAL COMPLICATIONS IN ONCOHEMATOLOGY , , , ,

S.V. Shtyrkova, S.R. Karagyulyan, K.I. Danishyan, S.K. Kravchenko, V.V. Troitskaya, L.A. Kuz’mina

Hematology Research Center under the Ministry of Health of the Russian Federation, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

For correspondence: Svetlana Vital’evna Shtyrkova, PhD, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; Tel.: +7(495)612-61-91; e-mail: sv-styrkova@mail.ru

For citation: Shtyrkova S.V., Karagyulyan S.R., Danishyan K.I., Kravchenko S.K., Troitskaya V.V., Kuz’mina L.A. Klin. Onkogematol. 2015; 8(3): 337-42. (In Russ.)

ABSTRACT

Background & Aims. In general surgical practice, the perianal infection is considered an emergency surgical defect and requires an urgent surgical intervention. However, the perianal infection complicating leukemia has its peculiar clinical manifestations and requires revision of the traditional approach. The aim of the study is to mark out possible risk factors of development of the perianal infection in patients with hematologic malignancy and to estimate efficacy of various treatment options.

Methods. Results of examination and treatment of 143 oncohematological patients with inflammatory anorectal pathology are presented. Among them, the largest group consisted of 110 patients with anal fissures and fistulas.

Results. The study demonstrated that the main mechanism of infection in these patients was associated with local damage of the wall of the anal canal: mechanical trauma ® crack ® paraproctitis or inflammation due to diarrhea or toxic effects of drugs ® anusitis ® cryptitis ® paraproctitis. In case of paraproctitis in patients with leukopenia, a combined parenteral antibiotic therapy is considered to be the basic treatment method.

Conclusion. In oncohematological patients when the underlying disease as well as the upcoming chemotherapy can lead to severe immunosuppression, the presence of persistent defect of the anal canal wall (anal fissure, fistula) should be considered as an indication for surgery. The surgical procedure reduces the risk of local inflammation and septic complications.

Keywords: perianal infection, disease of the anal canal, hematologic malignancies, leukemia, chemotherapy.

Received: May 19, 2015

Accepted: June 3, 2015

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