Mixed chimerism following allogeneic bone marrow transplantation: cases report

K.N. Melkova, N.V. Gorbunova, T.Z. Cherniavskaya

FSBI «N.N. Blokhin Russian Cancer Research Center» RAMS, Moscow, Russian Federation


ABSTRACT

Cimerism monitoring after the bone marrow transplantation (BMT) by a method based on the quantitative polymerase chain reaction (PCR), is important for the assessment of efficiency of transplantation, early identification of recurrence and timely correction of therapy. Clinical examples of the mixed chimerism after allogeneic BMT are presented.


Keywords: allogeneic transplantation, chimerism, mixed chimerism, bone marrow, hematopoietic stem cells.

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REFERENCES

  1. Appelbaum F.R., Forman S. J., Negrin R.S., Blume K.G. Thomas’ Hematopoietic Cell Transplantation, 4th ed. Malden: Blackwell Publishing Ltd., 2009: 316–27.
  2. Blum W., Brown R., Lin H.-S. et al. Low-dose (550 cGy), single-exposure total body irradiation and cyclophosphamide: Consistent, durable engraftment of related-donor peripheral blood stem cells with low treatment-related mortality and fatal organ toxicity. Biol. Blood Marrow Transplant. 2002; 8(11): 608–18.
  3. Tutschka P.J., Copelan E.A., Klein J.P. Bone Marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 1987; 70(5): 1382–8.
  4. Munker R., Lasarus H.M., Atkinson K. The BMT Data Book, 2nd ed. Cambridge University Press, 2009: 331–56.
  5. Matutes E., Pickl W.F., van’t Veer M. et al. Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Blood 2011; 117: 3163–71.
  6. Румянцев А.Г., Масчан А.А. Трансплантация гемопоэтических стволовых клеток у детей. М.: МИА, 2003: 405. [Rumyantsev A.G., Maschan A.A. Transplantatsiya gemopoeticheskikh stvolovykh kletok u detei (Hematopoietic stem cell transplantation in children). M.: MIA, 2003: 405.]