quality of life

Quality of life and symptom profile in patients with chronic myeloid leukemia receiving dasatinib as а second-line therapy due to intolerance or resistance to imatinib

CLINICAL PRESENTATION, DIAGNOSIS, AND MANAGEMENT OF MYELOID MALIGNANCIES , , ,

Ionova1,2, D. Fedorenko1,2, T. Nikitina1, and K. Kurbatova1

1 N.I. Pirogov National Medico-surgical Center, Moscow, Russian Federation

2 International Center for Quality of Life Studies, Saint-Petersburg, Russian Federation

ABSTRACT

The article is focused on preliminary results of the observational study “Quality of life and symptom profile in imatinib-resistant or intolerant patients with chronic myeloid leukemia during disease-modifying treatment” (2011–2012). 56 imatinib-resistant or intolerant patients with chronic myeloid leukemia in chronic phase were included in the preliminary analysis. It was shown that prior to treatment with dasatinib more than one third of patients had severe or critical quality of life deterioration. Patients treated with standard doses of imatinib during the first-line treatment reported better quality of life than patients treated with high doses of imatinib. After 12 months of treatment with dasatinib, the majority of patients showed complete or partial cytogenetic response (62 %); most of the patients with complete cytogenetic response were treated with standard doses of imatinib during the first-line treatment (19 % vs 8 %). During treatment with dasatinib, stabilization of quality of life parameters was recorded with a slight trend towards improved vitality, mental health, and pain scales. In the majority of patients (68 %), the treatment response as improved or stabilized quality of life was observed. During treatment with dasatinib, severity of the most frequent disease- or treatment-specific symptoms decreased. In this observational study, it was shown that dasatinib therapy in the real-world practice is effective both in terms of clinical parameters and patient-reported outcomes, and characterized by good tolerability.

Keywords: quality of life, symptom profile, chronic myeloid leukemia, dasatinib.

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