signaling pathways

Application of Modern Genome Technologies in Treatment of Lymphomas

REVIEWS , , ,

MV Nemtsova1, MV Maiorova2

1 Russian Medical Academy of Postgraduate Education, 2/1 Barrikadnaya str., Moscow, Russian Federation, 125993

2 PA Hertzen Moscow Oncology Research Institute, 3 2-y Botkinskii pr-d, Moscow, Russian Federation, 125284

For correspondence: Marina Vyacheslavovna Nemtsova, DSci, Professor, 2/1 Barrikadnaya str., Moscow, Russian Federation, 125993; Tel: +7(499)252-21-04; e-mail: nemtsova_m_v@mail.ru

For citation: Nemtsova MV, Maiorova MV. Application of Modern Genome Technologies in Treatment of Lymphomas. Clinical oncohematology. 2016;9(3):265-70 (In Russ).

DOI: 10.21320/2500-2139-2016-9-3-265-270

ABSTRACT

Modern achievements in genomics and cancer biology have provided an unprecedented body of knowledge regarding the molecular pathogenesis of lymphoma. Genome-wide association studies and modern computer technologies demonstrated that various histological and immunomorphological subtypes of lymphomas differ at the molecular level, and result from various oncogenic mechanisms. It is clear that the variability of clinical symptoms presented by patients with lymphomas is based on the heterogeneity of tumor cells and features of the molecular pathogenesis. Based on data obtained, strategies for the development of new drugs for treatment of lymphoma have been proposed, including identification of the molecular pathogenesis, assessment of the significance of each stage for the development of tumors and synthesis of a drug with a targeted effect. As a result, several new classes of molecular targeted agents for treatment of lymphomas have been proposed and are being tested in clinical trials. In the modern era of personalized medicine, correct targeted therapy for each type of lymphoma characterized by a unique molecular mechanism of tumor formation is a major challenge in lymphoma treatment.

Keywords: lymphoma, genes expression profile, microRNA, signaling pathways, NF-kB.

Received: February 13, 2016

Accepted: March 14, 2016

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