Childhood testicular diffuse large B-cell lymphoma

T.T. Valiev1, A.M. Kovrigina2, I.N. Serebryakova3, E.V. Mikhailova1, A.V. Popa1, G.L. Mentkevich1

1-Paediatric Research Institute of FSBI «Named after N.N. Blokhin Russian Cancer Research Center» RAMS, Moscow.

2-FSBI «Haematology Research Center of The Ministry of Health of the Russian Federation», Moscow, Russian Federation

3-Clinical Oncology Research Institute of FSBI «Named after N.N. Blokhin Russian Cancer Research Center» RAMS, Moscow, Russian Federation


ABSTRACT

Non-Hodgkin’s lymphomas with primary testis involvement is a rare heterogeneous group of lymphoid tumours. In adults testicular lymphomas (TL) are characterized by aggressive clinical progression, frequent relapses and metastases to CNS, and poor response to standard therapy. According to literature data, pediatric TL presented as clinical cases. In the article Diffuse large B-cell TL in 10-year old boy presented. Authors discuss in details successful intensive chemotherapy treatment.


Keywords: testicular lymphoma, diagnosis, treatment, children

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REFERENCES

  1. Petrescu A., Dobrea C., Vasilicа M. et al. Primary malignant lymphoma of the testis. Rom. J. Morphol. Embryol. 2005; 46(2): 83–6.
  2. Kondo T., Wada H., Yata K. et al. Seven patients with stage I and II primary testicular lymphoma. Rinsho Ketsueki. 2002; 43(6): 473–6.
  3. Darby S., Hancock B.W. Localised non-Hodgkin lymphoma of the testis: the Sheffield Lymphoma Group experience. Int. J. Oncol. 2005; 26(4): 1093–9.
  4. Licci S., Morelli L., Covello R. Primary mantle cell lymphoma of the testis. Ann. Hematol. 2011; 90(4): 483–4.
  5. Li D., Xie P., Mi C. Primary testicular diffuse large B-cell lymphoma shows an activated B-cell-like phenotype. Pathol. Res. Pract. 2010; 206(9): 611–5.
  6. Chan J.T., Tsang W.Y., Lau W.H. et al. Aggressive T/NK cell lymphoma presenting as testicular tumour. Cancer 1996; 77: 1198–205.
  7. Тумян Г.С., Ковригина А.М., Тимофеева О.Л. и др. Особенности клинического течения и прогноз больных неходжкинской лимфомой с первичной локализацией в яичке. Совр. онкол. 2006; 8(4): 22–6.
  8. Saha P.K., Sakai H., Nomata K. et al. Malignant lymphoma of the testis presenting as primary testicular tumor. Hinyokika Kiyo 1991; 37(9): 1061–4.
  9. Feugier P., Virion J., Tilly H. Incidence and risk factors for central nervous system occurrence in elderly patients with diffuse large B-cell lymphoma: influence of rituximab. Ann. Oncol. 2004; 15: 129–33.
  10. Asensio A.J., Besses C., Palacin A. et al. Primary testicular lymphoma. A report of 3 cases. Med. Clin. (Barc.) 1994; 103(9): 339–41.
  11. Takeuchi Y., Sawada Y., Yabuki D. et al. Testicular malignant lymphoma: a case report. Hinyokika Kiyo 2003; 49(11): 675–8.
  12. Heller K.N., Teruya-Feldstein J., La Quaglia M.P. et al. Primary follicular lymphoma of the testis: excellent outcome following surgical resection without adjuvant chemotherapy. J. Pediatr. Hematol. Oncol. 2004; 26(2): 104–7.
  13. Koksal Y., Yalcin B., Uner A. et al. Primary testicular Burkitt lymphoma in a child. Pediatr. Hematol. Oncol. 2005; 22(8): 705–9.
  14. Bacon C.M., Ye H., Diss T.C. et al. Primary follicular lymphoma of the testis and epididymis in adults. Am. J. Surg. Pathol. 2007; 31(7): 1050–8.
  15. Finn L.S., Viswanatha D.S., Belasco J.B. et al. Primary follicular lymphoma of the testis in childhood. Cancer 1999; 85(7): 1626–35.
  16. Shahab N., Doll D.C. Testicular lymphoma. Semin. Oncol. 1999; 26(3): 259–69.
  17. Bavai D.P., Roger A.J., Arino B.A. et al. Primary testicular lymphoma. Report of two cases and bibliographic review. Arch. Esp. Urol. 2008; 61(4): 527–31.