thoracoscopy

Biopsy of Lungs and Pleura in Hematologic Center

LYMPHOID TUMORS , , , ,

SR Karagyulyan, KI Danishyan, VS Shavlokhov, MA Silaev, GM Galstyan, AV Tochenov, LA Kuz’mina, IV Efimov, SA Shutov, YuV Pliskunova, IA Shupletsova, AM Kovrigina

Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

For correspondence: Maksim Anatol’evich Silaev, PhD, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; Tel.: +7(495)612-61-91; e-mail: max-blood@mail.ru

For citation: Karagyulyan SR, Danishyan KI, Shavlokhov VS, et al. Biopsy of Lungs and Pleura in Hematologic Center. Clinical oncohematology. 2016;9(1):42–7 (In Russ).

DOI: 10.21320/2500-2139-2016-9-1-42-47

ABSTRACT

Background & Aims. Morphological, immunohistochemical, immunophenotypic, cytogenetic, molecular and genetic and other examinations of tissues affected by oncohematological diseases are obligatory. The aim of this paper is to evaluate findings of lung and pleura biopsies in different medical conditions using two basic techniques: thoracoscopy and diagnostic thoracotomy.

Methods. Results of morphological examination of lung lesions in patients hospitalized in the Hematology Research Center under the Ministry of Health of the Russian Federation are presented. From 2004 till 2014, 76 biopsies of lung and/or parietal pleura were performed in 73 patients aged 19–77 years via thoracoscopic (48) and/or thoracotomic (28) approach.

Results. No thoracoscopy- and thoracotomy-related complications were observed. Bioptate examinations proved to be informative in 66 (86.7%) patients. Lung lesions were most common in lymphoproliferative diseases. Lung involvement in cancer or metastases was twice as common as it has been expected before the biopsy. On the contrary, expected tuberculosis nature of lung lesions in 5 patients was confirmed only in 2 of them. In 18 cases (23.7 %), the cause of lung lesion was other than the expected one, and appropriate adjustments of the therapy were made.

Conclusion. New less invasive methods of biopsy combined with complex laboratory diagnosing comply with current requirements and permit making a correct diagnosis of a pathological process located in lungs.

Keywords: lung biopsy, thoracoscopy, lung lesion, morphological verification, acute respiratory insufficiency.

Received: August 28, 2015

Accepted: December 26, 2015

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Video-Assisted Thoracoscopic Surgery in Diagnosing Lymphomas

LYMPHOID TUMORS , , ,

IG Komarov1,2, SYu Sletina1, MI Komarov2, АА Sukhov1

1 N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

2 Russian Medical Academy of Postgraduate Education, 23 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Igor’ Gennad’evich Komarov, DSci, Professor, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel.: +7(499)324-12-70; e-mail: komarovig@mail.ru

For citation: Komarov IG, Sletina SYu, Komarov MI, Sukhov AA. Video-Assisted Thoracoscopic Surgery in Diagnosing Lymphomas. Clinical oncohematology. 2016;9(1):30–41 (In Russ).

DOI: 10.21320/2500-2139-2016-9-1-30-41

ABSTRACT

This article continues a series of papers dwelling on endo-surgery techniques in diagnosing lymphomas. It describes the history of the thoracoscopic surgery and its potential and current use when malignant lymphoproliferative diseases with involvement of chest organs and tissues. It provides brief description of basic instruments, equipment and technique of surgical interventions via the thoracic access. It lists indications and contraindications for the thoracoscopic surgery. In addition, the paper presents analysis of video-assisted thoracoscopic surgeries in 178 patients with suspected malignant lymphoproliferative diseases. During these surgeries, samples for further morphological assessment were obtained from all patients. Lymphomas were confirmed in 120 patients. The article contains two case reports on the video-assisted thoracoscopic interventions performed.

Keywords: lymphoma, diagnostics, video-assisted surgery, thoracoscopy.

Received: November 6, 2015

Accepted: December 24, 2015

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