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Treatment of Advanced Stage Hodgkin’s Lymphoma: Literature Review

REVIEWS , , , ,

AA Leont’eva, EA Demina

N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Anna Aleksandrovna Leont’eva, graduate student, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel.: +7(499)324-90-89; e-mail: aurevoir-nut@yandex.ru

For citation: Leont’eva AA, Demina EA. Treatment of Advanced Stage Hodgkin’s Lymphoma: Literature Review. Clinical oncohematology. 2015;8(3):255–66 (In Russ).

ABSTRACT

Over the past decade, major research centers with large databases in Europe and the USA have conducted a comprehensive analysis of the effectiveness of treatment programs, delayed treatment-related complications and long-term survival of patients with advanced stage Hodgkin’s lymphoma. This analysis allowed us to develop new, more effective programs and introduce them into practical medicine, as well as to start searching for less toxic treatment options. However, in Russian scientific literature, this complex analysis has not been presented. Available publications and scientific investigations cover only some aspects of diagnosis and treatment of Hodgkin’s lymphoma or selectively discuss the problem of complications. The proposed literature review allows the reader to see the changes in the approach to management of advanced-stage Hodgkin’s lymphoma over the last 75 years: from absolutely pessimistic prognosis for the disease to modern high achievements with further improvement of treatment options for this disease.

Keywords: Hodgkin’s lymphoma, advanced stages, treatment, effectiveness of treatment, toxicity.

Received: February 20, 2015

Accepted: May 28, 2015

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