VIRAL INFECTIONS IN ONCOHEMATOLOGY

Chronic hepatitis C and hematological malignancies

VIRAL INFECTIONS IN ONCOHEMATOLOGY , , ,

A.O. Bueverov1 and P.O. Bogomolov2

1 I.M. Sechenov First Moscow State Medical University, RF MH, Moscow, Russian Federation

2 M.F. Vladimirsky Moscow Regional Research-and-Clinical Institute, Moscow, Russian Federation

ABSTRACT

Reactivation of chronic HCV-infection in cases of drug immunosuppression occurs relatively infrequently and rarely manifests itself as clinically significant liver injury. Certain alertness is required when such patients are treated with monoclonal antibodies in combination with glucocorticoids. Due to the extremely limited potentials of etiotropic therapies for HCV-infection in patients receiving immunosuppressive drugs for hematological malignancies, it is reasonable to follow the approaches similar to those in drug-induced hepatitis.

Keywords: chronic hepatitis C, immunosuppressive drugs, viral reactivation, drug-induced liver injury.

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REFERENCES

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Chronic hepatitis C and hematological malignancies

VIRAL INFECTIONS IN ONCOHEMATOLOGY , , ,

A.O. Bueverov1 and P.O. Bogomolov2

1 I.M. Sechenov First Moscow State Medical University, RF MH, Moscow

2 M.F. Vladimirsky Moscow Regional Research-and-Clinical Institute, Moscow

ABSTRACT

Reactivation of chronic HCV-infection in cases of drug immunosuppression occurs relatively infrequently and rarely manifests itself as clinically significant liver injury. Certain alertness is required when such patients are treated with monoclonal antibodies in combination with glucocorticoids. Due to the extremely limited potentials of etiotropic therapies for HCV-infection in patients receiving immunosuppressive drugs for hematological malignancies, it is reasonable to follow the approaches similar to those in drug-induced hepatitis.

Keywords: chronic hepatitis C, immunosuppressive drugs, viral reactivation, drug-induced liver injury.

Chronic hepatitis B and hematological malignancies

VIRAL INFECTIONS IN ONCOHEMATOLOGY , , ,

A.O. Buyeverov1, P.O. Bogomolov2

1 I.M. Sechenov First Moscow State University, RF Ministry of Health, Moscow, Russian Federation

2 M.F. Vladimirsky Moscow Regional Research-and-Clinical Institute, Moscow, Russian Federation

ABSTRACT

The active usage of monoclonal antibodies in therapy for hematology malignancies made reactivation of hepatitis B virus (HBV) infection one of the major health problems. Monoclonal antibodies are also used in solid tumors, rheumatic, gastroenterological, and skin diseases. Identification of patients with active, inactive, or latent HBV infection with the high risk of reactivation and appropriate antiviral therapy decreases the risk of liver damage and allows the complete course of cancer treatment. Preventive anti-HBV therapy is based on nucleoside analogues that should be chosen in accordance to their efficacy and considering the risk of resistant viral strain selection during long-term treatment. Existing preventive regimens require improvement that warrants further prospective trials for elaboration of optimal recommendations. Thus, prevention of HBV infection reactivation in patients receiving immunosuppressive drugs should include nucleoside analogues according to the HBV infection phase, as well as the therapeutic regimen and duration of treatment.

Keywords: chronic hepatitis B, immunosuppression, nucleoside analogues, entecavir.

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