Prognostic Value of the Degree of Tumor Tissue Infiltration by CD15-Positive Granulocytes in Nodular Sclerosis Classical Hodgkin’s Lymphoma

AUTOIMMUNE THROMBOCYTOPENIA

EA Perfilova, DA D’yakonov, MS Minaev

Kirov Research Institute of Hematology and Transfusiology, 72 Krasnoarmeiskaya ul., Kirov, Russian Federation, 610027

For correspondence: Elena Aleksandrovna Perfilova, PhD in Veterinary Medicine, 72 Krasnoarmeiskaya ul., Kirov, Russian Federation, 610027; Tel.: +7(996)896-08-67; e-mail: lperf78@gmail.com

For citation: Perfilova EA, D’yakonov DA, Minaev MS. Prognostic Value of the Degree of Tumor Tissue Infiltration by CD15-Positive Granulocytes in Nodular Sclerosis Classical Hodgkin’s Lymphoma. Clinical oncohematology. 2022;15(3):253–8. (In Russ).

DOI: 10.21320/2500-2139-2022-15-3-253-258

ABSTRACT

Classical Hodgkin’s lymphoma (cHL) nodular sclerosis type is one of the most common malignant lymphoproliferative diseases among younger people. The tumor is considered to be potentially curable. However, despite successful application of standard treatment methods, primary resistance and relapses occur. At present, many researchers focus on studying the value of tumor microenvironment in the prognosis of the course and progression of cHL, aiming at identifying new therapeutic targets. The present paper shows that the relative count of CD15-positive granulocytes in patients with favorable course of the disease is significantly lower than in therapy-refractory patients. The cut-off of tumor microenvironment cells expressing CD15 was 8 %. The data obtained provide the basis for determining prognostic value of CD15-positive granulocytes in nodular sclerosis cHL and presenting this cell pool as a potential therapeutic target.

Keywords: classical Hodgkin’s lymphoma, nodular sclerosis, CD15 granulocytes, tumor microenvironment.

Received: April 8, 2022

Accepted: June 17, 2022

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REFERENCES

  1. Демина Е.А., Тумян Г.С., Моисеева Т.Н. Лимфома Ходжкина. Клинические рекомендации. Современная онкология. 2020;22(2):6–33.
    [Demina EA, Tumyan GS, Moiseeva TN. Hodgkin’s lymphoma. Clinical guidelines. Sovremennaya onkologiya. 2020;22(2):6–33. (In Russ)]
  2. Российские клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний. Под ред. И.В. Поддубной, В.Г. Савченко. М.: Буки Веди, 2018. 356 с.
    [Poddubnaya IV, Savchenko VG, eds. Rossiiskie klinicheskie rekomendatsii po diagnostike i lecheniyu limfoproliferativnykh zabolevanii. (Russian clinical guidelines on diagnosis and treatment of lymphoproliferative disorders.) Moscow: Buki Vedi Publ.; 2018. 356 р. (In Russ)]
  3. Мочкин Н.Е., Н.Е., Саржевский В.О., Дубинина Ю.Н. и др. Результаты лечения классической лимфомы Ходжкина, включающего высокодозную химиотерапию с трансплантацией аутологичных гемопоэтических стволовых клеток, в НМХЦ им. Н.И. Пирогова. Клиническая онкогематология. 2018;11(3):234–40. doi: 10.21320/2500-2139-2018-11-3-234-240.
    [Mochkin NE, Sarzhevskii VO, Dubinina YuN, et. al. Outcome of Classical Hodgkin’s Lymphoma Treatment Based on High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation: The Experience in the NI Pirogov Russian National Medical Center of Surgery. Clinical oncohematology. 2018;11(3):234–40. doi: 10.21320/2500-2139-2018-11-3-234-240. (In Russ)]
  4. Беляева Е.С., Сусулева Н.А., Валиев Т.Т. Значение интенсивной химиотерапии для лечения детей с распространенными стадиями лимфомы Ходжкина. РМЖ. Мать и дитя. 2020;3(2):149–54. doi: 10.32364/2618-8430-2020-3-2-149-154.
    [Belyaeva ES, Susuleva NA, Valiev TT. The importance of intensive chemotherapy for advanced Hodgkin lymphoma in children. Russian Journal of Woman and Child Health. 2020;3(2):149–54. doi: 10.32364/2618-8430-2020-3-2-149-154. (In Russ)]
  5. Олейник Е.К., Шибаев М.И., Игнатьев К.С. Микроокружение опухоли: формирование иммунного профиля. Медицинская иммунология. 2020;22(2):207–20.
    [Oleinik EK, Shibaev MI, Ignat’ev KS. Tumor microenvironment: the formation of the immune profile. Meditsinskaya immunologiya. 2020;22(2):207–20. (In Russ)]
  6. Sionov RV, Fridlender ZG, Granot Z. The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment. Cancer Microenviron. 2015;8(3):125–58. doi: 10.1007/s12307-014-0147-5.
  7. Uribe-Querol E, Rosales C. Neutrophils in Cancer: Two Sides of the Same Coin. J Immunol Res. 2015;2015:983698. doi: 10.1155/2015/983698.
  8. Лисяный Н.И., Лисяный А.А. Нейтрофилы и онкогенез. Клиническая онкология. 2018;8(1):40–5.
    [Lisyanyi NI, Lisyanyi AA. Neutrophils and oncogenesis. Klinicheskaya onkologiya. 2018;8(1):40–5. (In Russ)]
  9. Потапнев М.П., Гущина Л.М., Мороз Л.А. Фенотипическая и функциональная гетерогенность субпопуляций нейтрофилов в норме и при патологии. Иммунология. 2019;5:84–96.
    [Potapnev MP, Gushchina LM, Moroz LA. Phenotypic and functional heterogeneity of neutrophil subpopulations in norm and pathology. Immunologiya. 2019;5:84–96. (In Russ)]
  10. Слуханчук Е.В. NETs и онкологический процесс. Акушерство, гинекология и репродукция. 2021;15(1):107–16. doi: 17749/2313-7347/ob.gyn.rep.2021.204.
    [Slukhanchuk EV. NETs and oncologic process. Akusherstvo, ginekologia i reprodukcia. 2021;15(1):107–16. doi: 10.17749/2313-7347/ob.gyn.rep.2021.204. (In Russ)]
  11. Fridlender ZG, Albelda SM. Tumor-associated neutrophils: Friend or foe? Carcinogenesis. 2012;33(5):949–55. doi: 10.1093/carcin/bgs123.
  12. Francischetti IMB, Alejo JC, Sivanandham R, et al. Neutrophil and Eosinophil Extracellular Traps in Hodgkin Lymphoma. HemaSphere. 2021;5(9):e633. doi: 10.1097/HS9.0000000000000633.
  13. Romano A, Pavoni C, Di Raimondo F, et al. The neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET-2-adapted HD0607 trial. Cancer Med. 2020;9(23):8735–46. doi: 10.1002/cam4.3396.
  14. Manfroi B, Moreaux J, Righini C, et al. Tumor-associated neutrophils correlate with poor prognosis in diffuse large B-cell lymphoma patients. Blood Cancer J. 2018;8(7):66. doi: 10.1038/s41408-018-0099-y.