chronic hepatitis C

Chronic hepatitis C and hematological malignancies

VIRAL INFECTIONS IN ONCOHEMATOLOGY , , ,

A.O. Bueverov1 and P.O. Bogomolov2

1 I.M. Sechenov First Moscow State Medical University, RF MH, Moscow, Russian Federation

2 M.F. Vladimirsky Moscow Regional Research-and-Clinical Institute, Moscow, Russian Federation

ABSTRACT

Reactivation of chronic HCV-infection in cases of drug immunosuppression occurs relatively infrequently and rarely manifests itself as clinically significant liver injury. Certain alertness is required when such patients are treated with monoclonal antibodies in combination with glucocorticoids. Due to the extremely limited potentials of etiotropic therapies for HCV-infection in patients receiving immunosuppressive drugs for hematological malignancies, it is reasonable to follow the approaches similar to those in drug-induced hepatitis.

Keywords: chronic hepatitis C, immunosuppressive drugs, viral reactivation, drug-induced liver injury.

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Chronic hepatitis C and hematological malignancies

VIRAL INFECTIONS IN ONCOHEMATOLOGY , , ,

A.O. Bueverov1 and P.O. Bogomolov2

1 I.M. Sechenov First Moscow State Medical University, RF MH, Moscow

2 M.F. Vladimirsky Moscow Regional Research-and-Clinical Institute, Moscow

ABSTRACT

Reactivation of chronic HCV-infection in cases of drug immunosuppression occurs relatively infrequently and rarely manifests itself as clinically significant liver injury. Certain alertness is required when such patients are treated with monoclonal antibodies in combination with glucocorticoids. Due to the extremely limited potentials of etiotropic therapies for HCV-infection in patients receiving immunosuppressive drugs for hematological malignancies, it is reasonable to follow the approaches similar to those in drug-induced hepatitis.

Keywords: chronic hepatitis C, immunosuppressive drugs, viral reactivation, drug-induced liver injury.