diagnosis

Video-Assisted Laparoscopic Surgeries in Lymphomas Diagnostics

LYMPHOID TUMORS , , ,

I.G. Komarov1,2, S.S. Stepanenkova3, M.I. Komarov2

1 Surgical Unit No. 2, N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

2 Subdepartment of Oncology, Russian Medical Academy of Postgraduate Education, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

3 Subdepartment of Oncology, A.I. Evdokimov Moscow State University of Medicine and Dentistry, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: I.G. Komarov, DSci, Professor, N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel: +7(499)324-12-70; e-mail: komarovig@mail.ru

For citation: Komarov I.G., Stepanenkova S.S., Komarov M.I. Video-Assisted Laparoscopic Surgeries in Lymphomas Diagnostics. Klin. Onkogematol. 2014; 7(4): 540–550 (In Russ.).

ABSTRACT

The article describes application of modern minimally invasive surgical technologies in oncohematology. The history of the video-assisted surgery is presented. Modern opportunities of the video-assisted laparoscopic surgery in diagnosing of malignant lymphoproliferative disorders were described. The main tools and the equipment, stages of intervention and technique used in video-assisted surgery are briefly described. Indications and contraindications for laparoscopic interventions are presented.

Keywords: lymphoma, diagnosis, video-assisted surgery, laparoscopy.

Accepted: September 17, 2014

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Rare Disease — Nodular Lymphocyte-Predominant Hodgkin’s Lymphoma: Literature Review and Own Data

LYMPHOID TUMORS , , , ,

E.A. Demina1, G.S. Tumyan1, A.A. Chekan1, M.Yu. Kichigina1, A.S. Antipova1, N.A. Probatova1, A.I. Pavlovskaya1, N.V. Kokosadze1, A.M. Kovrigina2, O.P. Trofimova1, E.A. Osmanov1

1 N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

2 Hematology Research Center under the Ministry of Health of the Russian Federation, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

For correspondence: E.A. Demina, DSci, Professor, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel: +7(499)324-90-89; e-mail: drdemina@yandex.ru

For citation: Demina E.A., Tumyan G.S., Chekan A.A., Kichigina M.Yu., Antipova A.S., Probatova N.A., Pavlovskaya A.I., Kokosadze N.V., Kovrigina A.M., Trofimova O.P., Osmanov E.A. Rare Disease — Nodular Lymphocyte-Predominant Hodgkin’s Lymphoma: Literature Review and Own Data. Klin. Onkogematol. 2014; 7(4): 522–532 (In Russ.).

ABSTRACT

Nodular lymphocyte-predominant Hodgkin’s lymphoma (NLPHL) is a rare disorder; it constitutes only 5 % of all cases of Hodgkin’s lymphoma (the morbidity rate is 1.5 per one million). The disease differs from classical Hodgkin’s lymphoma (cHL) in both immunohistochemical (marked CD20 expression in LP cells) and clinical features (prevalence of the early stage disease, indolent course with delayed relapses and trends toward transformation into diffuse large B cell lymphoma). Since the number of patients in prospective NLPHL-focused trials is limited, treatment algorithms have been based on retrospective data; these are usually obtained from cHL and indolent B cell lymphoma treatment strategies. Patients rarely die from NLPHL; in fact, secondary malignancies and other treatment related toxicities generally contribute to overall mortality. Over the past decade, there has been a series of NLPHL-related publications describing prescription of rituximab for newly diagnosed diseases and for relapses, including patients at high risk of diseases transformation. Besides, the role of the “wait and watch”, radiation treatment, and chemotherapy has been discussed. Our own experience in the use of rituximab in NLPLH patients demonstrated its efficacy at different stages and at different phases of the disease.

Keywords: nodular lymphocyte-predominant Hodgkin’s lymphoma, diagnosis, clinical characteristics, treatment, rituximab.

Accepted: September 8, 2014

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Lymphomas in HIV-Infected Patients: Literature Review

REVIEWS , , , , , , ,

A.V. Pivnik1, N.V. Seregin2, Yu.G. Parkhomenko3,4, O.A. Tishkevich4, A.M. Kovrigina5, Е.B. Likunov6

1 N.N. Pletnev Moscow Clinical Research Center, Department of Health, Moscow, Russian Federation

2 Moscow Municipal Cancer Dispensary No. 3, Moscow, Russian Federation

3 Research Institute of Human Morphology, RAMS, Moscow, Russian Federation

4 Clinical Infectious Diseases Hospital No. 2, Department of Health, Moscow, Russian Federation

5 Hematology Research Center, RF MH, Moscow, Russian Federation

6 American Medical Center, Moscow, Russian Federation

Address correspondence to: pivnikav@gmail.com

For citation: Pivnik A.V., Seregin N.V., Parkhomenko Yu.G., Tishkevich O.A., Kovrigina A.M., Likunov E.B. Lymphomas in HIV-Infected Patients: Literature Review. Klin. onkogematol. 2014; 7(3): 264–77 (In Russ.).

ABSTRACT

This review presents data on incidence, pathogenesis, diagnosis, and treatment of lymphoid malignancies in HIV-infected patients. Articles published by Russian and foreign authors are being reviewed. The principle role of decreased CD4+ lymphocyte count in development of secondary diseases in HIV patients is emphasized. Data on the structure of death causes in HIV-infected patients published by Russian authors are presented. They demonstrate that lymphoma is the 5th most common death cause (of 6 leading death causes). Hodgkin’s lymphoma in HIV-infected patients is not discussed in the review, because its pathogenesis differs from that of aggressive lymphomas and requires a separate discussion.

Keywords: lymphomas in HIV-infected patients, HIV, AIDS, secondary disorders, death causes, pathogenesis, diagnosis, treatment.

Accepted: May 15, 2014

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Optimization of diagnosis and treatment of Burkitt’s lymphoma in children, adolescents, and young adults

CLINICAL PRESENTATION, DIAGNOSIS, AND MANAGEMENT OF LYMPHOID MALIGNANCIES , , , , , ,

T.T. Valiyev1, Ye.A. Baryakh2, P.A. Zeynalova3, A.M. Kovrigina2, S.K. Kravchenko2, T.N. Obukhova2, N.А. Falaleyeva3, A.I. Senderovich3, I.N. Serebryakova3, I.V. Kaminskaya1, A.S. Levashov1, and G.L. Mentkevich1

1 Pediatric Oncology and Hematology Research Institute, N.N. Blokhin Russian Cancer Center, Moscow, Russian Federation

2 Hematology Research Center, RF Ministry of Health, Moscow, Russian Federation

3 Clinical Oncology Research Institute, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation

ABSTRACT

We present the combined experience of the leading centers in diagnosis and treatment of Burkitt’s lymphoma (BL) in children, adolescents, and young adults, that is the first one in the national scientific literature. It includes immunolomorphologic and cytogenetic criteria of BL. The clinical features of BL in various age groups and treatment outcomes according to B-NHL-BFM 90/95 and CODOX-M/IVAC programs are described. Also, the treatment outcomes according to the original national LB-M-04 protocol are shown. The place of rituximab in BL treatment is discussed.

Keywords: Burkitt’s lymphoma, children, adolescents, young adults, clinical features, diagnosis, treatment.

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Evolution of concepts for diagnosis and treatment of Burkitt’s lymphoma

EXPERIMENTAL STUDIES , , ,

T.T. Valiev1 and E.A. Baryakh2

1 Pediatric Oncology and Hematology Institute, N.N. Blokhin Russian Cancer Research Center, RAMS, Moscow, Russian Federation

2 Hematology Research Center, RF MH, Moscow, Russian Federation

ABSTRACT

The issues of diagnosis and treatment of the most aggressive lymphoid tumor, namely, Burkitt’s lymphoma (BL), are presented in the historical context. The clinical and laboratory features of endemic and sporadic BL variants are described. Possible mechanisms of Epstein-Barr virus and Plasmodium falciparum involvement in BL pathogenesis are suggested. Also, the morphologic, immunologic and cytogenetic BL diagnostic criteria are described. Based on molecular and genetic features, the issues of differential diagnosis with the heterogeneous group of diffuse large B-cell and highly aggressive mature B-cell lymphomas with additional proto-oncogene aberrations («double» and «triple» hit lymphomas) are presented. BL therapy and the role of rituximab in it is emphasized.

Keywords: Burkitt’s lymphoma, clinical presentation, diagnosis, treatment.

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Interdigitating dendritic cell sarcoma: case report and literature review

RARE HEMATOLOGICAL TUMORS AND SYNDROMES , ,

P.A. Zejnalova1, А.I. Pavlovskaya1, T.T. Valiev2, and N.V. Kokosadze1

1 Clinical Oncology Research Institute, N.N. Blokhin Cancer Research Center, RAMS, Moscow, Russian Federation

2 Pediatric Oncology and Hematology Research Institute, N.N. Blokhin Cancer Research Center, RAMS, Moscow, Russian Federation

ABSTRACT

We present the literature data and the authors’ observation of interdigitating dendritic cell sarcoma (IDCS), a very rare tumor consisting of histiocytic and dendritic cells. Due to variability in clinical presentation with nodal and/or extranodal involvement and immunomorphological characteristics of this sarcoma, differential diagnosis with non-Hodgkin’s lymphomas, melanoma, follicular dendritic cell sarcoma, and Langerhans cell histiocytosis is necessary. Here, we describe a clinical case of IDCS with cervical lymph node involvement and successful treatment with a CHOP program and subsequent irradiation. No generally accepted treatment strategy exists so far. Currently used methods include surgery, irradiation, and chemotherapy, but treatment outcomes need to be optimized.

Keywords: Interdigitating dendritic cell sarcoma, diagnosis, treatment.

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 REFERENCES

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Childhood testicular diffuse large B-cell lymphoma

DIAGNOSIS AND TREATMENT OF LYMPHOID TUMORS , , ,

T.T. Valiev1, A.M. Kovrigina2, I.N. Serebryakova3, E.V. Mikhailova1, A.V. Popa1, G.L. Mentkevich1

1-Paediatric Research Institute of FSBI «Named after N.N. Blokhin Russian Cancer Research Center» RAMS, Moscow.

2-FSBI «Haematology Research Center of The Ministry of Health of the Russian Federation», Moscow, Russian Federation

3-Clinical Oncology Research Institute of FSBI «Named after N.N. Blokhin Russian Cancer Research Center» RAMS, Moscow, Russian Federation

ABSTRACT

Non-Hodgkin’s lymphomas with primary testis involvement is a rare heterogeneous group of lymphoid tumours. In adults testicular lymphomas (TL) are characterized by aggressive clinical progression, frequent relapses and metastases to CNS, and poor response to standard therapy. According to literature data, pediatric TL presented as clinical cases. In the article Diffuse large B-cell TL in 10-year old boy presented. Authors discuss in details successful intensive chemotherapy treatment.

Keywords: testicular lymphoma, diagnosis, treatment, children

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