pathogenesis

The Role of BAALC-Expressing Leukemia Precursor Cells in the Pathogenesis of Myelodysplastic Syndromes

AUTOIMMUNE THROMBOCYTOPENIA , ,

NN Mamaev, MV Latypova, AI Shakirova, TL Gindina, MM Kanunnikov, NYu Tsvetkov, IM Barkhatov, SN Bondarenko, MD Vladovskaya, EV Morozova

RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022

For correspondence: Prof. Nikolai Nikolaevich Mamaev, MD, PhD, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022; e-mail: nikmamaev524@gmail.com

For citation: Mamaev NN, Latypova MV, Shakirova AI, et al. The Role of BAALC-Expressing Leukemia Precursor Cells in the Pathogenesis of Myelodysplastic Syndromes. Clinical oncohematology. 2022;15(1):62–8. (In Russ).

DOI: 10.21320/2500-2139-2022-15-1-62-68

ABSTRACT

The present paper provides evidence for a high detection rate of BAALC gene overexpression, also combined with WT1 gene overexpression, in patients with myelodysplastic syndromes (MDS) and FISH-verified chromosome defects. The BAALC and WT1 gene expression profiling in 16 MDS patients (6 out of them received allogeneic hematopoietic stem cell transplantation) showed an increased BAALC expression in 14 patients. The expression level in 2 patients was near the cut-off. Low expression levels were identified in a female patient with isolated 5q deletion in karyotype and also with its combination with complex karyotype. On the other hand, the highest expression levels were reported in patients with normal karyotype and 3q26 locus rearrangement, which was associated with EVI1 gene overexpression. Since the BAALC expression level, at least in patients with the major (except for М3 and М7) FAB-variants of acute myeloid leukemias (AML), was closely associated with BAALC-producing precursor cells of leukemia clone, a profound study of this phenomenon in MDS patients seems to be important for understanding the finest mechanisms underlying the pathogenesis of AML and AML relapses on the level of precursor cells.

Keywords: myelodysplastic syndromes, BAALC and WT1 genes, overexpression, post-transplantation relapses, BAALC-producing precursor cells, pathogenesis, prognosis.

Received: July 7, 2021

Accepted: November 4, 2021

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Статистика Plumx английский

REFERENCES

  1. Gadji M, Pozzo AR. From cellular morphology to molecular and epigenetic anomalies of myelodysplastic syndromes. Genes Chromos Cancer. 2019;58(7):474–83. doi: 10.1002/gcc.22689.
  2. Schanz J, Cevik N, Fonatsch C, et al. Detailed analysis of clonal evolution and cytogenetic evolution patterns in patients with myelodysplastic syndromes (MDS) and related myeloid disorders. Blood Cancer J. 2018;8(3):28. doi: 10.1038/s41408-018-0061-z.
  3. Bersanelli M, Travaglino E, Meggendorfer M, et al. Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes. J Clin Oncol. 2021;39(11):1223–33. doi: 10.1200/JCO.20.01659.
  4. Papaemmanuil E, Gerstung M, Malcovati L, et al. Сlinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122(22):3616–27. doi: 10.1182/blood-2013-08-518886.
  5. Minetto P, Guolo F, Cavio M, et al. Combined assessment of WT1 and BAALC gene expression at diagnosis may improve leukemia-free survival prediction in patients with myelodysplastic syndromes. Leuk Res. 2015;39(8):866–73. doi: 10.1016/leukres.2015/04/011.
  6. Мамаев Н.Н., Шакирова А.И., Бархатов И.М. и др. Ведущая роль BAALC-экспрессирующих клеток-предшественниц в возникновении и развитии посттрансплантационных рецидивов у больных острыми миелоидными лейкозами. Клиническая онкогематология. 2020;13(1):75–88. doi: 10.21320/2500-2139-2020-13-1-75-88.
    [Mamaev NN, Shakirova AI, Barkhatov IM, et al. Crucial Role of BAALC–Expressing Progenitor Cells in Emergence and Development of Post-Transplantation Relapses in Patients with Acute Myeloid Leukemia. Clinical oncohematology. 2020;13(1):75–88. doi: 10.21320/2500-2139-2020-13-1-75-88. (In Russ)]
  7. Mamaev NN, Shakirova AI, Barkhatov IM, et al. Crucial role of BAALC-expressing leukemic precursors in origin and development of posttransplant relapses in patients with acute myeloid leukemias. Int J Hematol. 2020;8(6):127–31. doi: 10.15406/htij.2020.08.00240.
  8. Mamaev NN, Shakirova AI, Barkhatov IM, et al. New opportunities for assay of leukemia initiating cells (LICs) participating in post-transplant relapse development in the patients with acute myeloid leukemia. 3rd Annual IACH Meeting, 1–3 October, 2020, Paris. Report #12.
  9. Mamaev NN, Shakirova AI, Gindina TL, et al. Quantitative study of BAALC- and WT1-expressing cell precursors in the patients with different cytogenetic and molecular AML variants treated with Gemtuzumab ozogamicin and hematopoietic stem cell transplantation. Cell Ther Transplant. 2021;10(1):55–62. doi: 10.18620/ctt-1866-8836-2021-10-1-55-62.
  10. Thol F, Kade S, Schlarmann C, et al. Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood. 2012;119(15):3578–84. doi: 10.1182/blood-2011-12-399337.
  11. Haferlach T, Nagata Y, Grossmann V, et al. Landscape of genetic lesions in 944 patients with myelodyspl astic sendromes. Leukemia. 2014;18(2):241–7. doi: 10.1038/leu.2013.336.
  12. Pauebelle E, Piesa A, Hayette S, et al. Efficacy of all-trans-retinoic acid in high risk acute myeloid leukemia with overexpression of EVI1. Oncol Ther. 2019;7(2):121–30. doi: 10.1007/s40487-019-0095-9.
  13. Field T, Perkins KJ, Huang Y, et al. 5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2010;45(2):255–60. doi: 10.1038/bmt.2009.134.
  14. Мамаев Н.Н., Шакирова А.И., Морозова Е.В., Гиндина Т.Л. EVI1-позитивные лейкозы и миелодиспластические синдромы: теоретические и клинические аспекты (обзор литературы). Клиническая онкогематология. 2021;14(1):103–17. doi: 10.21320/2500-2139-2021-14-1-103-117.
    [Mamaev NN, Shakirova AI, Morozova EV, Gindina TL. EVI1-Positive Leukemias and Myelodysplastic Syndromes: Theoretical and Clinical Aspects (Literature Review). Clinical oncohematology. 2021;14(1):103–17. doi: 10.21320/2500-2139-2021-14-1-103-117. (In Russ)]
  15. Geoffroy М-С, Esnault C, de The H. Retinoids in hematology: a timely revival? Blood. 2021;137(18):2429–37. doi: 10.1182/blood.2020010100.

Stevens-Johnson Syndrome after Treatment of Female Patient with Small Lymphocytic B-Cell Lymphoma, Autoimmune Hemolytic Anemia and Antiphospholipid Antibody Syndrome with Rituximab

COMPLICATIONS OF ANTITUMOR TREATMENT , , , , ,

AL Melikyan, IN Subortseva, AM Kovrigina, TI Kolosheinova, EK Egorova, EI Pustovaya

Hematology Research Center under the Ministry of Health of the Russian Federation, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

For correspondence: Irina Nikolaevna Subortseva, PhD, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; Tel.: +7(495)612-44-71; e-mail: soubortseva@yandex.ru

For citation: Melikyan AL, Subortseva IN, Kovrigina AM, et al. Stevens-Johnson Syndrome after Treatment of Female Patient with Small Lymphocytic B-Cell Lymphoma, Autoimmune Hemolytic Anemia and Antiphospholipid Antibody Syndrome with Rituximab Clinical oncohematology. 2017;10(1): 120–7 (In Russ).

DOI: 10.21320/2500-2139-2017-10-1-120-127

ABSTRACT

Stevens-Johnson syndrome is a severe delayed type systemic allergic reaction which affects the skin and mucous membranes. In adults, Stevens-Johnson syndrome is usually caused by the administration of drugs or a malignant process. The paper presents a case of Stevens-Johnson syndrome after the treatment of a female patient with small lymphocytic B-cell lymphoma, autoimmune hemolytic anemia and antiphospholipid antibody syndrome with rituximab. A rare combination of Stevens-Johnson syndrome and small lymphocytic B-cell lymphoma of small lymphocytes, as well as the development of severe delayed type systemic allergic reaction to introduction of rituximab are of special interest. A detailed medical history and the clinical manifestations of the disease allowed to diagnose Stevens-Johnson syndrome at early stages and prescribe an adequate therapy. As a result of the treatment, the patient’s condition has improved considerably. Symptoms of general toxicity were arrested completely; there was a complete epithelization of erosive defects. Therefore, the presented clinical observation shows that timely diagnosis, complex drug therapy, and comprehensive care can cure the diseases as soon as possible and prevent complications.

Keywords: Stevens-Johnson syndrome, pathogenesis, clinical manifestations, diagnosis, treatment, rituximab.

Received: July 28, 2016

Accepted: December 6, 2016

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REFERENCES

  1. Mockenhaupt M. The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol. 2011;7(6):803–13. doi: 10.1586/eci.11.66.
  2. Gerull R, Nelle M, Schaible T. Toxic epidermal necrolysis and Stevens-Johnson syndrome: A review. Crit Care Med. 2011;39(6):1521–32. doi: 10.1097/CCM.0b013e31821201ed.
  3. Yamane Y, Matsukura S, Watanabe Y, et al. Retrospective analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in 87 Japanese patients—Treatment and outcome. Allergol Int. 2016;65(1):74–81. doi: 10.1016/j.alit.2015.09.001.
  4. Teh LK, Selvaraj M, Bannur Z, et al. Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B*15:02. J Pharm Pharm Sci. 2016;19(1):147–60. doi: 10.18433/J38G7X.
  5. Chung W-H, Hung S-I. Genetic Markers and Danger Signals in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Allergol Int. 2010;59(4):325–332 doi: 10.2332/allergolint.10-rai-0261.
  6. Chantaphakul H, Sanon T, Klaewsongkram J. Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis. Exp Ther Med. 2015;10(2):519–24. doi: 10.3892/etm.2015.2549.
  7. Rzany B, Mockenhaupt M, Baur S, et al. Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome and toxic epidermal necrolysis in Germany (1990–1992): Structure and results of a population-based registry. J Clin Epidemiol. 1996;49(7):769–73. doi: 10.1016/0895-4356(96)00035-2.
  8. Schneck J, Fagot JP, Sekula P, et al. Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective study on patients included in the prospective EuroSCAR study. J Am Acad Dermatol. 2008;58(1):33–40. doi: 10.1016/j.jaad.2007.08.039.
  9. Bastuji-Garin S, Fouchard N, Bertocchi M, et al. SCORTEN: A severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 2000;115(2):149–53. doi: 10.1046/j.1523-1747.2000.00061.x.
  10. Creamer D, Walsh SA, Dziewulski P, et al. UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016. J Plast Reconstr Aesthet Surg. 2016;69(6):736–41. doi: 10.1016/j.bjps.2016.04.018.
  11. Tripathi A, Ditto AM, Grammer LC, et al. Corticosteroid therapy in an additional 13 cases of Stevens–Johnson syndrome: a total series of 67 cases. Allergy Asthma Proc. 2000;21(2):101–5. doi: 10.2500/108854100778250914.
  12. Kardaun SH, Jonkman MF. Dexamethasone pulse therapy for Stevens–Johnson syndrome/toxic epidermal necrolysis. Acta Derm Venereol. 2007;87(2):144–8. doi: 10.2340/00015555-0214.
  13. Viard I, Wehrli P, Bullani R, et al. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science. 1998;282(5388):490–3. doi: 10.1126/science.282.5388.490.
  14. French LE, Trent JT, Kerdel FA. Use of intravenous immunoglobulin in toxic epidermal necrolysis and Stevens–Johnson syndrome: our current understanding. Int Immunopharmacol. 2006;6(4):543–9. doi: 10.1016/j.intimp.2005.11.012.
  15. Prins C, Kerdel FA, Padilla RS, et al. TEN-IVIG Study Group. Treatment of toxic epidermal necrolysis with high-dose intravenous immunoglobulins: multicenter retrospective analysis of 48 consecutive cases. Arch Dermatol. 2003;139(1):26–32. doi: 10.1001/archderm.139.1.26.
  16. Kim KJ, Lee DP, Suh HS, et al. Toxic epidermal necrolysis: analysis of clinical course and SCORTEN-based comparison of mortality rate and treatment modalities in Korean patients. Acta Derm Venereol. 2005;85:497–502.
  17. Bamichas G, Natse T, Christidou F, et al. Plasma exchange in patients with toxic epidermal necrolysis. Ther Apher. 2002;6(3):225–8. doi: 10.1046/j.1526-0968.2002.00409.x.
  18. Egan CA, Grant WJ, Morris SE, et al. Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis. J Am Acad Dermatol. 1999;40(3):458–61. doi: 10.1016/S0190-9622(99)70497-4.
  19. Kamanabroo D, Schmitz-Landgraf W, Czarnetzki BM. Plasmapheresis in severe drug-induced toxic epidermal necrolysis. Arch Dermatol. 1985;121(12):1548–9. doi: 10.1001/archderm.1985.01660120074023.
  20. Kasi PM, Tawbi HA, Oddis CV, Kulkarni HS. Clinical review: Serious adverse events associated with the use of rituximab – a critical care perspective. Crit Care. 2012;16(4):231. doi: 10.1186/cc11304.
  21. Lowndes S, Darby A, Mead G, Lister A. Stevens-Johnson syndrome after treatment with rituximab. Ann Oncol. 2002;13(12):1948–50. doi: 10.1093/annonc/mdf350.
  22. Johnson PW, Glennie MJ. Rituximab: mechanisms and applications. Br J Cancer. 2001;85(11):1619–23. doi: 10.1054/bjoc.2001.2127.
  23. Суборцева И.Н. Клинико-биологические особенности первичной экстранодальной диффузной В-крупноклеточной лимфомы: Дис. ¼ канд. мед. наук. М., 2013. 138 с.
    [Subortseva IN. Kliniko-biologicheskie osobennosti pervichnoi ekstranodal’noi diffuznoi B-krupnokletochnoi limfomy. (Clinical and biological features of the primary extranodal diffuse large B-cell lymphoma.) [dissertation] Moscow; 2013. 138 р. (In Russ)]
  24. Foran JM, Gupta RK, Cunningham D, et al. A UK multicentre phase II study of rituximab in patients with follicular lymphoma, with PCR monitoring of molecular response. Br J Haematol. 2000;109(1):81–8. doi: 10.1046/j.1365-2141.2000.01965.x.
  25. Davis TA, White CA, Grillo-Lopez AJ, et al. Single agent monoclonal antibody efficacy in bulky non-Hodgkin’s lymphoma. J Clin Oncol. 1999;17(6):1851–7.
  26. Maloney DG, Grillo-Lopez AJ, White CA, et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin’s lymphoma. Blood. 1997;90(6):2188–95.
  27. Piro LD, White CA, Grillo-Lopez AJ, et al. Extended rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin’s lymphoma. Ann Oncol. 1999;10:655–61.
  28. Byrd JC, Murphy T, Howard RS, et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukaemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol. 2001;19(8):2153–64.
  29. Suzan F, Ammor M, Ribrag V. Fatal reactivation of cytomegalovirus infection after use of rituximab for a post-transplantation lymphoproliferative disorder. N Engl J Med. 2001;345(13):1000. doi: 10.1056/NEJM200109273451315.
  30. Walewski J, Kraszewska E, Mioduszewska O, et al. Rituximab (MabtheraTM, RituxanTM) in patients with recurrent indolent lymphoma. Med Oncol. 2001;18(2):141–8. doi: 10.1385/mo:18:2:141.
  31. Palmieri TL, Greenhalgh DG, Saffle JR, et al. A multicenter review of toxic epidermal necrolysis treated in U.S. Burn centers at the end of the twentieth century. J Burn Care Rehabil. 2002;23(2):87–96. doi: 10.1097/00004630-200203000-00004.
  32. Cummins DL, Mimouni D, Tzu J, et al. Lichenoid paraneoplastic pemphigus in the absence of detectable antibodies. J Am Acad Dermatol. 2007;56(1):153–9. doi: 10.1016/j.jaad.2006.06.007.

 

Primary Mediastinal (Thymic) Large B-Cell Lymphoma

REVIEWS , , , , , ,

GS Tumyan, IZ Zavodnova, MYu Kichigina, EG Medvedovskaya

NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Gayane Sergeevna Tumyan, DSci, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel: +7(499)324-98-29; e-mail: gaytum@mail.ru

For citation: Tumyan GS, Zavodnova IZ, Kichigina MYu, Medvedovskaya EG. Primary Mediastinal (Thymic) Large B-Cell Lymphoma. Clinical oncohematology. 2017;10(1):13–24 (In Russ).

DOI: 10.21320/2500-2139-2017-10-1-13-24

ABSTRACT

Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is one of the primary extranodal tumors and originates from thymic medulla B cells. The disease is more common in young women and declares itself by mainly locally advanced growth within the anterior upper mediastinum with frequent involvement of chest organs. PMBCL has specific morphological, immunological, and genetic characteristics that permit to differentiate it from other similar diseases: diffuse large В-cell lymphoma, nodular sclerosis Hodgkin’s lymphoma, and mediastinal gray zone lymphoma. Immunochemotherapy with subsequent irradiation of the residual mediastinal tumor is the standard treatment of PMBCL. No benefits of one drug therapy over another have been demonstrated to date in controlled studies. Application of new imaging techniques (PET/CT) may result in withdrawal of the radiotherapy in some PMBCL patients without impairment of delayed survival rates.

Keywords: primary mediastinal (thymic) large B-cell lymphoma, primary extranodal lymphomas, diagnosis, pathogenesis, morphological, immunological/genetic characteristics, treatment.

Received: August 22, 2016

Accepted: December 17, 2016

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REFERENCES

  1. Benjamin SP, McCormack LJ, Effler DB, et al. Primary lymphatic tumors of the mediastinum. Cancer. 1972;30(3):708–12. doi: 10.1002/1097-0142(197209)30:3<708::AID-CNCR2820300318>3.0.CO;2–5.
  2. Lichtenstein AK, Levine A, Taylor CR, et al. Primary mediastinal lymphoma in adults. Am J Med. 1980;68(4):509–14. doi: 10.1016/0002-343(80)90294-6.
  3. National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin’s Lymphoma Pathologic Classification Project. Cancer. 1982;49(10):2112–35. doi: 10.1002/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2–2.
  4. Stansfeld AG, Diebold J, Noel H, et al. Updated Kiel classification for lymphomas. Lancet. 1988;1(8580):292–3. doi: 10.1016/S0140-6736(88)90367-4.
  5. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84(5):1361–92. doi: 10.1016/S0968-6053(00)80051-4.
  6. Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. Lyon: IARC Press; 2008. doi: 10.1002/9781118853771.ch51.
  7. Cazals-Hatem D, Lepage E, Brice P, et al. Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (“Groupe d’Etude des Lymphomes de l’Adulte”) study. Am J Surg Pathol. 1996;20(7):877–88. doi: 10.1097/00000478-199607000-00012.
  8. Harris NL. Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications. Mod Pathol. 2013;26(Suppl 1):S57–70. doi: 10.1038/modpathol.2012.182.
  9. Kanavaros P, Gaulard P, Charlotte F, et al. Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas. Am J Pathol. 1995;146(3):735–41.
  10. Pileri SA, Zinzani PL, Gaidano G, et al. Pathobiology of primary mediastinal B-cell lymphoma. Leuk Lymphoma. 2003;44(Suppl 3):S21–6. doi: 10.1080/10428190310001623810.
  11. Loddenkemper C, Anagnostopoulos I, Hummel M, et al. Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas. J Pathol. 2004;202(1):60–9. doi: 10.1002/path.1485.
  12. De Leval L, Ferry JA, Falini B, et al. Expression of bcl-6 and CD10 in primary Mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? Am J Surg Pathol. 2001;25(10):1277–82. doi: 10.1097/00000478-200110000-00008.
  13. Rosenwald A, Wright G, Leroy K, et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003;198(6):851–62. doi: 10.1084/jem.20031074.
  14. CopieBergman C, Plonquet A, Alonso MA, et al. MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas. Mod Pathol. 2002;15:1172–80. doi: 10.1097/01.MP.0000032534.81894.B3.
  15. Joos S, Otano-Joos MI, Ziegler S, et al. Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood. 1996;87(4):1571–8.
  16. Feuerhake F, Kutok JL, Monti S, et al. NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood. 2005;106(4):1392–9. doi: 10.1182/blood-2004-12-4901.
  17. Zhang B, Wang Z, Li T, et al. NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis. Blood. 2007;110(2):743–51. doi: 10.1182/blood-2006-11-058446.
  18. Meier C, Hoeller S, Bourgau C, et al. Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas. Mod Pathol. 2009;22(3):476–87. doi: 10.1038/modpathol.2008.207.
  19. Rossi D, Cerri M, Capello D, et al. Aberrant somatic hypermutation in primary mediastinal large B-cell lymphoma. Leukemia. 2005;19(12):2363–6. doi: 10.1038/sj.leu.2403982.
  20. Steidl C, Gascoyne RD. The molecular pathogenesis of primary mediastial large B-cell lymphoma. Blood. 2011;118(10):2659–69. doi: 10.1182/blood-2011-05-326538.
  21. Martelli M, Di Rocco A, Russo E, et al. Primary mediastinal lymphoma: diagnosis and treatment options. Expert Rev Hematol. 2014;8(2):173–86. doi: 10.1586/17474086.2015.994604.
  22. Eberle FC, Salaverria I, Steidl C, et al. Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations. Mod Pathol. 2011;24(12):1586–97. doi: 10.1038/modpathol.2011.116.
  23. Eberle FC, Rodriguez-Canales J, Wei L, et al. Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin’s lymphoma and primary mediastinal large B-cell lymphoma. Haematologica. 2011;96(4):558–66. doi: 10.3324/haematol.2010.033167.
  24. Moller P, Lammler B, Herrmann B, et al. The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression. Immunology. 1986;59(3):411–7. doi: 10.1007/bf00705408.
  25. Hamlin PA, Portlock CS, Straus DJ, et al. Primary mediastinal large B-cell lymphoma: optimal therapy and prognostic factor analysis in 141 consecutive patients treated at Memorial Sloan Kettering from 1980 to 1999. Br J Haematol. 2005;130(5):691–9. doi: 10.1111/j.1365-2141.2005.05661.x.
  26. Jacobson JO, Aisenberg AC, Lamarre L, et al. Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapy. Cancer. 1988;62(9):1893–8. doi: 10.1002/1097-0142(19881101)62:9<1893::AID-CNCR2820620904>3.0.CO;2-X.
  27. Zinzani PL, Martelli M, Magagnoli M, et al. Treatment and clinical management of primary mediastinal large B-cell lymphoma with sclerosis: MACOP-B regimen and mediastinal radiotherapy monitored by (67)Gallium scan in 50 patients. Blood. 1999;94(10):3289–93.
  28. Bishop PC, Wilson WH, Pearson D, et al. CNS involvement in primary mediastinal large B-cell lymphoma. J Clin Oncol. 1999;17(8):2479–85.
  29. Savage K, Al-Rajhi N, Voss N, et al. Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience. Ann Oncol. 2006;17:123–30. doi: 10.1016/s0360-3016(00)80463-0.
  30. Zinzani PL, Martelli M, Bertini M, et al. Induction chemotherapy strategies for primary mediastinal large B-cell lymphoma with sclerosis: a retrospective multinational study on 426 previously untreated patients. Haematologica. 2002;87(12):1258–6. doi: 10.3816/clm.2009.n.074.
  31. Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma. N Engl J Med. 1993;328(14):1002–6. doi: 10.1056/NEJM199304083281404.
  32. Levitt LJ, Aisenberg AC, Harris NL, et al. Primary non-Hodgkin’s lymphoma of the mediastinum. Cancer. 1982;50(11):2486–92. doi: 10.1002/1097-0142(19821201)50:11<2486::AID-CNCR2820501138>3.0.CO;2-G.
  33. Todeschini G, Ambrosetti A, Meneghini V, et al. Mediastinal large-B-cell lymphoma with sclerosis: a clinical study of 21 patients. J Clin Oncol. 1990;8(5):804–8.
  34. Bertini M, Orsucci L, Vitolo U, et al. Stage II large B-cell lymphoma with sclerosis treated with MACOP-B. Ann Oncol. 1991;2(10):733–7.
  35. Falini B, Venturi S, Martelli M, et al. Mediastinal large B-cell lymphoma: clinical and immunohistological findings in 18 patients treated with different third-generation regimens. Br J Haematol. 1995;89(4):780–9. doi: 10.1111/j.1365-2141.1995.tb08415.x.
  36. van Besien K, Kelta M, Bahaguna P. Primary mediastinal B-cell lymphoma: a review of pathology and management. J Clin Oncol. 2001;19(6):1855–64.
  37. Zinzani PL, Martelli M, Bendandi M, et al. Primary mediastinal large B-cell lymphoma with sclerosis: a clinical study of 89 patients treated with MACOP-B chemotherapy and radiation therapy. Haematologica. 2001;86(2):187–91.
  38. Zinzani PL, Stefoni V, Finolezzi E, et al. Rituximab combined with MACOP-B or VACOP-B and radiation therapy in primary mediastinal large B-cell lymphoma: a retrospective study. Clin Lymph Myel. 2009;9(5):381–5. doi: 10.3816/CLM.2009.n.074.
  39. Dunleavy K, Pittaluga S, Maeda LS, et al. Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma. N Engl J Med. 2013;368(15):1408–16. doi: 10.1056/NEJMoa1214561.
  40. Moskowitz CH, Schoder H, Teruya-Feldstein J, et al. Risk-adapted dose-dense immunochemotherapy determined by interim FDG-PET in Advanced-stage diffuse large B-Cell lymphoma. J Clin Oncol. 2010;28(11):1896–903. doi: 10.1200/JCO.2009.26.5942.
  41. Savage KJ, Yenson PR, Shenkier T, et al. The outcome of primary mediastinal large B-cell lymphoma (PMBCL) in the R-CHOP treatment era. Blood. 2012;120(Suppl 1–2): Abstract 303.
  42. Martelli M, Ceriani L, Zucca E, et al. [18F]fluorodeoxyglucose positron emission tomography predicts survival after chemoimmunotherapy for primary mediastinal large B-cell lymphoma: results of the International Extranodal Lymphoma Study Group IELSG-26 Study. J Clin Oncol. 2014;32(17):1769–75. doi: 10.1200/JCO.2013.51.7524.
  43. Pinnix CC, Dabaja B, Ahmed MAet al. Single-institution experience in the treatment of primary mediastinal B cell lymphoma treated with immunochemotherapy in the setting of response assessment by 18fluorodeoxyglucose positron emission tomography. Int J Radiat Oncol Biol Phys. 2015;92(1):113–21. doi: 10.1016/j.ijrobp.2015.02.006.
  44. Sehn LH, Antin JH, Shulman LN, et al. Primary diffuse large B-cell lymphoma of the mediastinum: outcome following high-dose chemotherapy and autologous hematopoietic cell transplantation. Blood. 1998;91(2):717–23.
  45. Kuruvilla J, Pintilie M, Tsang R, et al. Salvage chemotherapy and autologous stem cell transplantation are inferior for relapsed or refractory primary mediastinal large B-cell lymphoma compared with diffuse large B-cell lymphoma. Leuk Lymphoma. 2008;49(7):1329–36. doi: 10.1080/10428190802108870.
  46. Hao Y, Chapuy B, Monti S, Sun HH. Selective JAK2 inhibition specifically decreases Hodgkin lymphoma and mediastinal large B-cell lymphoma growth in vitro and in vivo. Clin Cancer Res. 2014;20(10):2674–83. doi: 10.1158/1078-0432.CCR-13-3007.
  47. Dunleavy K, Wilson W. Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? Blood. 2015;125(1):33–9. doi: 10.1182/blood-2014-05-575092.
  48. Berger R, Rotem-Yehudar R, Slama G, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res. 2008;14(10):3044–51. doi: 10.1158/1078-0432.CCR-07-4079.

Lymphomas in HIV-Infected Patients: Literature Review

REVIEWS , , , , , , ,

A.V. Pivnik1, N.V. Seregin2, Yu.G. Parkhomenko3,4, O.A. Tishkevich4, A.M. Kovrigina5, Е.B. Likunov6

1 N.N. Pletnev Moscow Clinical Research Center, Department of Health, Moscow, Russian Federation

2 Moscow Municipal Cancer Dispensary No. 3, Moscow, Russian Federation

3 Research Institute of Human Morphology, RAMS, Moscow, Russian Federation

4 Clinical Infectious Diseases Hospital No. 2, Department of Health, Moscow, Russian Federation

5 Hematology Research Center, RF MH, Moscow, Russian Federation

6 American Medical Center, Moscow, Russian Federation

Address correspondence to: pivnikav@gmail.com

For citation: Pivnik A.V., Seregin N.V., Parkhomenko Yu.G., Tishkevich O.A., Kovrigina A.M., Likunov E.B. Lymphomas in HIV-Infected Patients: Literature Review. Klin. onkogematol. 2014; 7(3): 264–77 (In Russ.).

ABSTRACT

This review presents data on incidence, pathogenesis, diagnosis, and treatment of lymphoid malignancies in HIV-infected patients. Articles published by Russian and foreign authors are being reviewed. The principle role of decreased CD4+ lymphocyte count in development of secondary diseases in HIV patients is emphasized. Data on the structure of death causes in HIV-infected patients published by Russian authors are presented. They demonstrate that lymphoma is the 5th most common death cause (of 6 leading death causes). Hodgkin’s lymphoma in HIV-infected patients is not discussed in the review, because its pathogenesis differs from that of aggressive lymphomas and requires a separate discussion.

Keywords: lymphomas in HIV-infected patients, HIV, AIDS, secondary disorders, death causes, pathogenesis, diagnosis, treatment.

Accepted: May 15, 2014

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REFERENCES

  1. Ship J.A., Wolff A., Selik R.M. Epidemiology of acquired immune deficiency syndrome in persons aged 50 years or older. J. Acquir. Immune Defic. Syndr. 1991; 4(1): 84–8.
  2. Lyles R.H., Munoz A., Yamashita T.E. et al. Natural history of HIV type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. J. Infect. Dis. 2000; 181: 872–80.
  3. Бобкова М.Р. Иммунитет и ВИЧ-инфекция (популярные лекции). М.: Олимпия Пресс, 2006. 240 с. [Bobkova M.R. Immunitet i VICh-infektsiya (populyarnye lektsii). (Immunity and HIV infection (popular lectures)). Moscow: Olimpiya Press Publ., 2006. 240 p.].
  4. Mellors J.W., Munoz A.M., Giorgi J.V. et al. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann. Intern. Med. 1997; 126: 946–54.
  5. UNAIDS Technical Update (UNAIDS Best Practice Collection: Technical Update). UNAIDS (1997b): HIV testing methods. Geneva: UNAIDS, November 1997.
  6. Покровский В.В., Ермак Т.Н., Беляева В.В. ВИЧ инфекция. Клиника, диагностика, лечение. М.: ГЭОТАР-Медиа, 2003: 356–60. [Pokrovskii V.V., Ermak T.N., Belyaeva V.V. VICh infektsiya. Klinika, diagnostika, lechenie. (HIV infection. Clinical picture, diagnosis, treatment). Moscow: GEOTAR-Media Publ., 2003. pp. 356–60].
  7. ВИЧ-инфекция и СПИД: национальное руководство. Под. ред. В.В. Пок ровского. М.: ГЭОТАР-Медиа, 2013. 608 с.  [Pokrovskii V.V., ed. VICh-infektsiya i SPID: natsional’noe rukovodstvo. (HIV and AIDS: national guidelines). Moscow: GEOTAR-Media Publ., 2013. 608 p.].
  8. Покровский В.И., Покровский В.В., Потекаев С.Н. и др. Первый случай СПИД у гражданина СССР. Тер. арх. 1988; 7: 10–14. [Pokrovskii V.I., Pokrovskii V.V., Potekaev S.N. et al. The first case of AIDS in a USSR resident. Ter. arkh. 1988; 7: 10–4. (In Russ.)].
  9. Тишкевич О.А., Шахгильдян В.И., Пархоменко Ю.Г. Структура ле- тальных исходов и патологическая анатомия у больных ВИЧ-инфекцией в Москве. Эпидемиол. и инфек. бол. 2004; 4: 42–6. [Tishkevich O.A., Shakhgil’dyan V.I., Parkhomenko Yu.G. The Structure of lethal outcomes and morbid anatomy in HIV infected patients in Moscow. Epidemiol. i infek. bol. 2004; 4: 42–6. (In Russ.)].
  10. Гармаева Т.Ц. Вирусные гепатиты В и С у больных заболеваниями системы крови: Автореф. дис. … д-ра мед. наук. М., 2012. [Garmaeva T.Ts. Virusnye gepatity B i C u bol’nykh zabolevaniyami sistemy krovi: Avtoref. dis. … d-ra med. nauk. (Viral hepatitis B and C in patients with blood diseases: Author’s abstract of doctor’s thesis). Moscow, 2012.].
  11. Gonzalez R., Jacobus J., Martin M. Investigating Neurocognitive Features of Hepatitis C Virus Infection in Drug Users: Potential Challenges and Lessons Learned from the HIV Literature. CID 2005; 41: S45–49.
  12. Hilsabeck R.C., Castellon S.A., Hinkin Ch.H. Neuropsychological Aspects of Coinfection with HIV and Hepatitis C Virus. CID 2005; 41: S38–44.
  13. Desai J., Mitnick R.J., Henry D.H., Llena J., Sparano J.A. Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-Hodgkin lymphoma. Cancer 1999; 86: 1840–7.
  14. Леви Дж.Э. ВИЧ и патогенез СПИДа: Пер. с англ., 3-е изд. М.: На- учный мир, 2010: 16. [Levy Jay A. HIV and the Pathogenesis of AIDS. 3rd edition. ASM Press, 2007, 643 p. (Russ. Ed. Levy J.A. VICh i patogenez SPIDa. Moscow: Nauchnyi Mir Publ., 2010. рр. 16.)].
  15. Allers K., Hutter G., Hofmann J. et al. Evidence for the cure of HIV infection 32 stem cell transplantation. Blood 2011; 117(10): 2791–9.D32/Dby CCR5
  16. Hosseini I., MacGabhann F., Thomas P.G. (eds.) APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study. PLoS One 2013; 8(5): e63984.
  17. Kenneth L.M., Johnson M., D’Aquila R.T. APOBEC3G Complexes Decrease Human Immunodeficiency Virus Type 1 Production. J. Virol. 2011; 85(18): 9314–26.
  18. Collins K.L., Chen B.K., Walker B.D., Baltimore D. HIV-1 protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 1998; 391: 397–401.
  19. Hammer S.M. Treatment for adult HIV infection: JAVA 2006; 296(7): 827–43.
  20. Hoffmann C., Chow K.U., Wolf E. et al. Strong impact of highly active antiretroviral therapy on survival in patients with human immunodeficiency virusassociated Hodgkin’s disease. Br. J. Haematol. 2004; 125: 455.
  21. Хоффман К., Кампс Б. Лечение ВИЧ-инфекции. Flying Publisher, 2005. 581 c. [Hoffmann C., Kamps B. HIV Therapy. Flying Publisher, 2005. 581 p. (Russ. Ed. Hoffmann C., Kamps B. Lechenie VICh-infektsii. Flying Publisher, 2005. 581 p.)].
  22. Бартлетт Дж. и др. Клинические аспекты ВИЧ-инфекции: Пер. с англ. М., 2013. 540 с. [Bartlett J. et al. Klinicheskie aspekty VICh-infekcii (Clinical aspects of HIV infection). Moscow, 2013. 540 p.].
  23. Ioachim H.L. Lymphadenopathies of HIV infection and AIDS. In: Benign and malignant lymphadenopathies. Ed. by G.A. Pangalis, A. Polliack. Harwood academic publisher, 1993: 159–70.
  24. Малый В.П. ВИЧ/СПИД (Новейший медицинский справочник). М.: Эксмо, 2009. 672 с. [Malyi V.P. VICh/SPID (Noveishii meditsinskii spravochnik) (HIV/AIDS (Up-todate manual)). Moscow: Eksmo Publ., 2009. 672 p.].
  25. Пивник А.В., Лукашев А.М., Туманова М.В. и др. Диагностика и ле- чение больных СПИД-ассоциированными лимфомами. Вестн. Моск. онкол. общества. 2008; 12: 553. [Pivnik A.V., Lukashev A.M., Tumanova M.V. et al. Diagnosis and treatment of patients with AIDS-associated lymphomas. Vestn. Mosk. onkol. obshchestva. 2008; 12: 553. (In Russ.)].
  26. Schuerman D.A. Clinical concerns: AIDS in the elderly. J. Gerontol. Nurs. 1994; 20(7): 11–7.
  27. Пархоменко Ю.Г., Тишкевич О.А., Шахгильдян В.И. Анализ аутопсий при ВИЧ-инфекции. Арх. пат. 2003; 3: 24–9. [Parkhomenko Yu.G., Tishkevich O.A., Shakhgil’dyan V.I. Analysis of autopsies in HIV infection. Arkh. pat. 2003; 3: 24–9. (In Russ.)].
  28. Mack K.A., Ory M.G. AIDS and older Americans at the end of the twentieth century. J. Acquir. Immune Defic. Syndr. 2003; 33(Suppl. 2): S68–75.
  29. Diamond C., Taylor T.H., Im T., Miradi M., Anton-Culver H. Improved survival and chemotherapy response among patients with AIDS-related Hodgkin’s lymphoma receiving highly active antiretroviral therapy. Hematol. Oncol. 2006; 10: 10.
  30. Powles T., Imami N., Nelson M., Gazzard B.G., Bower M. Effects of combination chemotherapy and HAART on immune parameters in HIV-1 associated lymphoma. AIDS 2002; 16: 531–6.
  31. Пивник А.В., Коровушкин В.Г., Пархоменко Ю.Г. и др. Дифференци- альная диагностика лимфаденопатий при ВИЧ/СПИД. Тер. арх. 2006; 4: 28–32. [Pivnik A.V., Korovushkin V.G., Parkhomenko Yu.G. et al. Differential diagnosis of lymphoadenopathies in HIV/AIDS. Ter. arkh. 2006; 4: 28–32. (In Russ.)].
  32. Пивник А.В., Коровушкин В.Г., Туаева А.О. и др. Тромбоцитопения при ВИЧ-инфекции. Тер. арх. 2008; 80(7): 75–80. [Pivnik A.V., Korovushkin V.G., Tuaeva A.O. et al. Thrombocytopenia in HIV infection. Ter. arkh. 2008; 80(7): 75–80. (In Russ.)].
  33. Малеев В.В., Полякова А.М., Кравченко А.В. Патогенетические механизмы нарушений системы гемостаза у больных ВИЧ-инфекцией. Эпидемиол. и инфек. бол. 2000; 3: 45–9. [Maleev V.V., Polyakova A.M., Kravchenko A.V. Pathogenetic mechanisms of hemostatic disorders in HIV infected patients. Epidemiol. i infek. bol. 2000; 3: 45–9. (In Russ.)].
  34. Stebbing J., Gazzard B., Mandalia S. et al. Antiretroviral treatment regimens and immune parameters in the prevention of systemic AIDS-related non-Hodgkin’s lymphoma. J. Clin. Oncol. 2004; 22(11): 2177–83.
  35. Young N.S., Gerson S.L., High K.A. Clinical Hematology. Philadelphia: Mosby Elsevier, 2006: 505–79.
  36. Февралева И.С., Глинщикова О.А., Макарик Т.В., Судариков А.Б. Мультиплексная диагностика вирусов гепатитов В, С и парвовируса В19 у больных, получающих множественные гемотрансфузии. Гематол. и транс- фузиол. 2008; 53(4): 54–6. [Fevraleva I.S., Glinshchikova O.A., Makarik T.V., Sudarikov A.B. Multiplex diagnosis of hepatitis B and C viruses and parvovirus B19 in patients receiving multiple hemotransfusions. Gematol. i transfuziol. 2008; 53(4): 54–6. (In Russ.)].
  37. Судариков А.Б. Молекулярная диагностика вирусов гепатита С, В, G и парвовируса B19 у гематологических больных: Автореф. дис. д-ра … биол. наук. М., 2012. [Sudarikov A.B. Molekulyarnaya diagnostika virusov gepatita S, V, G i parvovirusa  B19 u gematologicheskikh bol’nykh: Avtoref. dis. … d-ra biol. nauk. (Molecular diagnosis of hepatitis C, B, G viruses and parvovirus B19 in hematological patients). Moscow, 2012.].
  38. Wu H., Kuritzkes D.R., Clemon D.R. et al. Characterization of viral dynamics in HIV type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. J. Infect. Dis. 1999; 179: 799–807.
  39. Ganellos G.P., Lister T.A., Sklar J.L. The Lymphomas. Philadelphia: W.B. Saunders, 1998: 399–413.
  40. Armitage J.O., Cavalli F., Longo D. Annual of Lymphoid Malignancies. Taylor & Francis, 2000: 112–9.
  41. Navarro W.H., Kaplan L.D. AIDS-related lymphoproliferative disease. Blood 2006; 107(1): 13–20. 42. Little R.F. AIDS-related non-Hodgkin’s lymphoma: etiology, epidemiology, and impact of highly active antiretroviral therapy. Leuk. Lymphoma 2003; 44(3): 63–8.
  42. Gerard L., Galicier L., Maillard A. et al. Systemic non-Hodgkin lymphoma in HIV-infected patients with effective suppression of HIV replication: persistent occurrence but improved survival. J. Acquir. Immune Defic. Syndr. 2002; 30: 478–84.
  43. Levine A.M., Seneviratne L., Espina B.M. et al. Evolving characteristics of AIDS-related lymphoma. Blood 2000; 96: 4084–90.
  44. Matthews G.V., Bower M., Mandalia S. et al. Changes in AIDS-related lymphoma since the introduction of HAART. Blood 2000; 96: 2730–4.
  45. Besson C., Goubar A., Gabarre J. et al. Changes in AIDS-related lymphoma since the era of HAART. Blood 2001; 98: 2339–44.
  46. Levine A.M. AIDS-related lymphoma. Semin. Oncol. Nurs. 2006; 22(2): 80–9.
  47. Aboulafia D.M., Pantanowitz L., Dezube B.J. AIDS-Related Non-Hodgkin Lymphoma: Still a Problem in the Era of HAART. AIDS 2004; 14(11): 605–17.
  48. Kadan-Lottick N.S., Skluzacek M.C., Gurney J.G. Decreasing incidence rates of primary central nervous system lymphoma. Cancer 2002; 95: 193–202.
  49. Franceschi S., Dal Maso L., La Vecchia C. Advances in the epidemiology of HIV-associated non-Hodgkin’s lymphoma and other lymphoid neoplasms. Intern. J. Cancer 1999; 83: 481–5.
  50. Cinque P., Brytting M., Vago L. et al. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system. Lancet 1993; 342: 398–401.
  51. Oriol A., Ribera J.M., Esteve J. et al. Lack of influence of human immunodeficiency virus infection status in the response to therapy and survival of adult patients with mature B-cell lymphoma or leukemia. Results of the PETHEMALAL3/97 study. Haematologica 2003; 88(4): 445–53.
  52. Mounier N., Spina M., Gabarre J. et al. AIDS-related non-Hodgkin lymphoma: final analysis of 485 patients treated with risk adapted intensive chemotherapy. Blood 2006; 107(10): 3832–40.
  53. Lim S.T., Karim R., Tulpule A., Nathwani B.N., Levine A.M. Prognostic Factors in HIV-Related Diffuse Large-Cell Lymphoma: Before Versus After Highly Active Antiretroviral Therapy. J. Clin. Oncol. 2005; 23(33): 8477–82.
  54. Carbone A., Cesarman E., Spina M. HIV-associated lymphomas and gamma-herpesviruses. Blood 2009; 113(6): 1213–24.
  55. Simonelli C., Spina M., Cinelli R. et al. Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study. J. Clin. Oncol. 2003; 21: 3948–54.
  56. Menendez J.A., Lilien D.L., Nanda А. et al. AIDS-Related Lymphoma. Abstr. Hematol. Oncol. 2005; 8(1): 20–30, 68–70.
  57. Delecluse H.J., Anagnostopoulos I., Dallenbach F. et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 1997; 89: 1413–20.
  58. Gisselbrecht C., Mounier N. Treatment of relapsed and refractory Hodgkin’s Lymphoma. In: Education program of the 10th congress of the European Hematology Association, 2005: 182–5.
  59. Gisselbrecht C., Mounier N. Treatment of poor prognosis non-Hodgkin’s lymphoma. In: Education program of the 10th congress of the European hematology association, 2005: 160–5.
  60. Bower M., Gazzard B., Mandalia S., Newsom-Davis T. et al. A prognostic index for systemic AIDS-related non-Hodgkin lymphoma treated in the era of highly active antiretroviral therapy. Ann. Intern. Med. 2005; 143: 265–73.
  61. Feigal E.G., Levine A.M., Biggar R.J. AIDS-related Cancers and Their Treatment. Marcel Dekker Inc., 2000: 97–124.
  62. Little R.F., Gutierrez M., Jaffe E.S. et al. HIV-Associated non-Hodgkin lymphoma: incidence, presentation, and prognosis. JAMA 2001; 285: 1880–5.
  63. Pauza C.D., Pyzalski R., Perlman S.B. et al. Positron emission tomography images of AIDS pathogenesis. Conf. Adv. AIDS Vaccine, 1997.
  64. Литвинов В.И., Макарова М.В., Краснова М.А. Нетуберкулезные микобактерии и микобактериозы. Эпидемиол. и инфек. бол. 2011; 6: 4–10. [Litvinov V.I., Makarova M.V., Krasnova M.A. Nontuberculous mycobacteria and mycobacteriosis. Epidemiol. i infek. bol. 2011; 6: 4–10. (In Russ.)].
  65. Литвинов В.И., Макарова М.В., Краснова М.А. Нетуберкулезные микобактерии. М.: МНПЦБТ, 2008. 256 с.  [Litvinov V.I., Makarova M.V., Krasnova M.A. Netuberkuleznye mikobakterii (Nontuberculous mycobacteria). Moscow: MNPTsBT Publ., 2008. 256 р.].
  66. Clarke C.A., Glaser S.L. Epidemiologic trends in HIV-associated lymphomas. Curr. Opin. Oncol. 2001; 13: 354–9.
  67. Clarke C.A., Glaser S.L. Epidemiologic trends in HIV-associated lymphomas. Curr. Opin. Oncol. 2003; 15: 267–90.
  68. Патологическая анатомия: национальное руководство. Под ред. М.А. Пальцева, Л.В. Кактурского, О.В. Зайратьянца. М.: ГЭОТАР-Медиа, 2011. 1264 с. [Pal’tsev M.A., Kakturskii L.V., Zairat’yants O.V., eds. Patologicheskaya anatomiya: natsional’noe rukovodstvo. (Morbid anatomy: national guidelines). Moscow: GEOTAR-Media Publ., 2011. 1264 p.].
  69. Stebbing J., Marvin V., Bower M. et al. The evidence-based treatment of AIDS-related non-Hodgkins lymphoma. Cancer Treat. Rev. 2004; 30: 249–53.
  70. Hartmann P., Rehwald U., Salzberger B. et al. BEACOPP therapeutic regimen for patients with Hodgkin’s disease and HIV infection. Ann. Oncol. 2003; 14: 1562–9.
  71. Antinori A., Cingolani A., Alba L. et al. Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy. AIDS 2001; 15: 1483–91.
  72. Chadburn A., Hyjek E., Mathew S. et al. KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am. J. Surg. Pathol. 2004; 28(11): 1401–16.
  73. Пивник А.В. Применение ритуксимаба у больных с ВИЧ-инфекцией. Клин. онкогематол. 2013; 6(1): 84–90.  [Pivnik A.V. The use of rituximab in patients with HIV infection. Klin. onkogematol. 2013; 6(1): 84–90. (In Russ.)].
  74. Lim S.T., Karim R., Nathwani B.N. et al. AIDS-related Burkitt’s lymphoma versus diffuse large cell lymphoma in the pre-highly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy. J. Clin. Oncol. 2005; 23: 4430–8.
  75. Boue F., Gabarre J., Gisselbrecht C. et al. CHOP chemotherapy plus Rituximab in HIV patients with high grade lymphoma – results of an ANRS Trial. Blood 2002; 22: 470a (abstract 1824).
  76. Dunleavy K., Wilson W.H. How I treat HIV-associated lymphoma. Blood 2012; 119(14): 3245–55.
  77. Krishnan A., Molina A., Zaia J. et al. Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas. Blood 2005; 105(2): 874–8.
  78. Sparano J.A., Wiernik P.H., Strack M. et al. Infusional cyclophosphamide, doxorubicin, and etoposide in human immunodeficiency virus- and human T-cell leukemia virus type I-related non-Hodgkin’s lymphoma: a highly active regimen. Blood 1993; 81: 2810–5.
  79. Cortes J., Thomas D., Rios A. et al. Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia. Cancer 2002; 94: 1492–9.
  80. Molina A., Zaia J., Krishnan A. Treatment of human immunodeficiency virus-related lymphoma with haematopoietic stem cell transplantation. Blood Rev. 2003; 17: 249–58.
  81. Navarro J.T., Ribera J.M., Oriol A. et al. Influence of HAART on response to treatment and survival in patients with AIDS-related non-Hodgkin’s lymphoma treated with cyclophosphamide, hydroxydoxorubicin, vincristine and prednisone. Br. J. Haematol. 2001; 112: 909–15.
  82. Барях Е.А., Кременецкая А.М., Кравченко С.К. и др. Новый короткий высокоинтенсивный протокол терапии лимфомы Беркитта у взрослых ЛБ- М-04: промежуточные результаты. Гематол. и трансфузиол. 2006; 51(6): 45–9. [Baryakh E.A., Kremenetskaya A.M., Kravchenko S.K. et al. New abridged highly intensive protocol LB-M-04 for treatment of Burkitt’s lymphoma in adults: interim results. Gematol. i transfuziol. 2006; 51(6): 45–9. (In Russ.)].
  83. Барях Е.А., Звонков Е.Е., Кременецкая А.М. и др. Лечение Беркитто- подобной лимфомы у взрослых. Тер. арх. 2005; 7: 53–8. [Baryakh E.A., Zvonkov E.E., Kremenetskaya A.M. et al. Treatment of Burkittlike lymphoma in adults. Ter. arkh. 2005; 7: 53–8. (In Russ.)].
  84. Пивник А.В., Пархоменко Ю.Г., Криволапов Ю.А. и др. Соматические проблемы ВИЧ-медицины: СПИД-ассоциированные лимфомы. Онкогема- тология 2007; 3: 27–37. [Pivnik A.V., Parkhomenko Yu.G., Krivolapov Yu.A. et al. Somatic problems of HIV medicine: AIDS-associated lymphomas. Onkogematologiya 2007; 3: 27–37. (In Russ.)].
  85. Kaplan L.D., Lee J.Y., Ambinder R.F. еt al. Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin’s lymphoma: AIDS-Malignancies Consortium Trial 010. Blood 2005; 106: 1538–43.
  86. Kaplan L.D., Scadden D.T. No benefit from Rituximab in a randomized phase III trial of CHOP with or without rituximiab for patients with HIV-associated non-Hodgkins lymphoma: AIDS-Malignancies Consortium study 010. Proc. Am. Soc. Clin. Oncol. 2003; 22: 564 (abstract 2268).
  87. Krishnan A., Molina A., Zaia J. et al. Autologous stem cell transplantation for HIV-associated lymphoma. Blood 2001; 98: 3857–9.