hematopoietic and lymphoid tissue malignancies

Local Immunity in Hematological Patients with Oropharyngeal Candidiasis

INFECTIONS IN ONCOHEMATOLOGY , , ,

E.Yu. Danilovа, N.V. Shabashova, E.V. Frolova, A.E. Uchevatkina, L.V. Filippova

I.I. Mechnikov North-West State Medical University under the Ministry of Health of Russia, 41 Kirochnaya str., Saint Petersburg, Russian Federation, 191015

For correspondence: Evgeniya Yur’evna Danilova, graduate student in the Department of Clinical Mycology, 41 Kirochnaya str., Saint Petersburg, Russian Federation, 191015; Tel.: +7(812)303-51-41; e-mail: danilovaimmuno@yandex.ru

For citation: Danilova EYu, Shabashova NV, Frolova EV, et al. Local Immunity in Hematological Patients with Oropharyngeal Candidiasis. Clinical oncohematology. 2015;8(4):436–441 (In Russ).

DOI: 10.21320/2500-2139-2015-8-4-436-441

ABSTRACT

Aim. To evaluate the incidence of oropharyngeal candidiasis (OFC) among oncohematological patients depending on the type of the malignancy and anti-tumor treatment, as well as to assess key cytokine levels in saliva samples.

Methods. 430 patients were enrolled in the study, and 85 samples of saliva were collected from patients with OFC (n = 38) and without it. The control group consisted of 19 healthy volunteers.

Results. The OFC incidence was 9 % and it did not depend on the immunomorphological type of the malignancy and the type of chemotherapy. Before the anti-tumor treatment, TNF-a, IL-17 and G-CSF levels in saliva samples were elevated in all patients. The TNF-a (p < 0.05) synthesis was decreased after the anti-tumor treatment. Besides, a tendency to reduced G-CSF and IL-17 production was found. In patients with OFC, MCP-1, IL-17, IFN-g levels were decreased.

Conclusion. In OFC patients with hematopoietic and lymphoid tissue malignancies, impairment of basic types of local antifungal protection was found.

Keywords: oropharyngeal candidiasis, hematopoietic and lymphoid tissue malignancies, local immunity, Candida spp.

Received: July 1, 2015

Accepted: November 9, 2015

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Primary Incidence of Hematological Malignancies in Saint Petersburg in 1990–2011 and Prognosis till 2021

ORGANIZATION OF PUBLIC HEALTH , ,

L.Yu. Zhiguleva, K.M. Abdulkadyrov

Russian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological Agency, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024

For correspondence: Lyubov’ Yur’evna Zhiguleva, PhD, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024; Tel.: +7(812)717-09-95; e-mail: RNIIHT@mail.ru

For citation: Zhiguleva LYu, Abdulkadyrov KM. Primary Incidence of Hematological Malignancies in Saint Petersburg in 1990–2011 and Prognosis till 2021. Clinical oncohematology. 2015;8(4):362–367 (In Russ).

DOI: 10.21320/2500-2139-2015-8-4-362-367

ABSTRACT

Background & Aims. Assessment of the incidence and dynamics of hematopoietic and lymphoid tissue malignancies is caused by the need in rational planning of hematological care, identification of risk factors in specific areas, and justification of prevention programs.

Methods. This paper analyzes the incidence and dynamics of the malignancies among the population of Saint Petersburg over the period from 1990 till 2011 and gives prognosis till 2021. Data from the Information Analysis Center of the Department of Public Healthcare under the Saint Petersburg Government and from Petrostat, a population cancer register (Saint Petersburg), were used. Besides, the paper analyzes materials of official reports Results of Activities in the Field of Public Healthcare of Saint Petersburg over the period from 2012 till 2013 and On Sanitary and Epidemiological Well-Being of Saint Petersburg Population over the period from 2010 till 2013, as well as data from the Federal State Statistics Service on the incidence of hematological malignancies in Russia. The sampled population was 19,456.

Results. The incidence of hematologic malignancies in Saint Petersburg is higher than that in Moscow, Russia and a number of other areas, and the extent of their occurrence among men is higher as compared to women. A steady growth of their incidence rate throughout the period under review has been revealed, with a maximum increasing rate in the working age.

Conclusion. According to the prognosis, by 2021, the incidence of hematopoietic and lymphoid tissue malignancies in Saint Petersburg will increase by 29.7 %. The findings suggest the increased need in specialized hematological care and its availability, and more efficient use of available resources.

Keywords: incidence, hematological care, hematopoietic and lymphoid tissue malignancies.

Received: April 1, 2015

Accepted: October 15, 2015

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