monoclonal antibodies

New Possibilities of Treatment for Relapsed/Refractory Multiple Myeloma: A Literature Review

REVIEWS , , ,

OM Votyakova

NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Ol’ga Mikhailovna Votyakova, PhD, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel.: 8(499)324-92-09; e-mail: omvtk@yandex.ru 24

For citation: Votyakova OM. New Possibilities of Treatment for Relapsed/Refractory Multiple Myeloma: A Literature Review. Clinical oncohematology. 2017;10(4):425–34 (In Russ).

DOI: 10.21320/2500-2139-2017-10-4-425-434

ABSTRACT

Despite improvements in the treatment of patients with newly diagnosed multiple myeloma (MM) through the introduction of new drugs and high-dose chemotherapy with autologous hematopoietic stem cell transplantation, relapses are still inevitable in all patients. The use of immunomodulatory agents (thalidomide, lenalidomide) and proteasome inhibitor bortezomib has improved the treatment of relapses. However, the disease progression lead to repeated relapses and eventually refractory MM. For these patients new therapeutic strategies are needed, including the development of more effective drugs within the existing classes and the study of new combinations, as well as searching new targets for the treatment of MM. We present the key clinical data on the efficacy and safety of the most promising proteasome inhibitors (carfilzomib, ixazomib), new generation immunomodulatory drug pomalidomide, and monoclonal antibodies (daratumumab and elotuzumab).

Keywords: proteasome inhibitors, immunomodulatory medication, monoclonal antibodies, multiple myeloma.

Received: March 14, 2017

Accepted: June 20, 2017

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Elotuzumab for Treatment of Multiple Myeloma (Literature Review)

LYMPHOID TUMORS , ,

OM Votyakova

NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

For correspondence: Ol’ga Mikhailovna Votyakova, PhD, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Tel: +7(499)324-92-09; e-mail: omvtk@yandex.ru

For citation: Votyakova OM. Elotuzumab for Treatment of Multiple Myeloma (Literature Review). Clinical oncohematology. 2016;9(4):438–45 (In Russ).

DOI: 10.21320/2500-2139-2016-9-4-438-445

ABSTRACT

Chemotherapy has been the main treatment option for multiple myeloma for several decades. However, a considerable increase in the life expectancy was observed in multiple myeloma patients when thalidomide, bortezomib and lenalidomide had been introduced into clinical practice. Nevertheless, the disease remains incurable and there is an unmet need in fundamentally new treatment methods. Elotuzumab is a humanized IgG1 monoclonal antibody that specifically targets SLAMF7, an antigen belonging to the signaling lymphocytic activation molecule family, with its high expression detected on myeloma cells. This review presents the mechanism of action of elotuzumab, preclinical data and the main clinical studies of this monoclonal antibody.

Keywords: monoclonal antibodies, elotuzumab, clinical studies, multiple myeloma.

Received: May 25, 2016

Accepted: June 15, 2016

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Monoclonal Antibodies: from Development to Clinical Application

REVIEWS , ,

YuI Budchanov

Tver’ Medical University, 4 Sovetskaya str., Tver’, Russian Federation, 170000

For correspondence: Yurii Ivanovich Budchanov, 3 1st per. Krasnoi Slobody, Tver’, Russian Federation, 170001; e-mail: budjur@mail.ru

For citation: Budchanov YuI. Monoclonal Antibodies: from Development to Clinical Application. Clinical oncohematology. 2016;9(3):237-44 (In Russ).

DOI: 10.21320/2500-2139-2016-9-3-237-244

ABSTRACT

The development of monoclonal antibodies (MABs) resulted in revolutionary achievements in diagnosing and treating of oncohematological disorders. The review dwells on the history of the development and improved technologies for production of monoclonal antibodies illustrated by anti-CD20-MABs which recognize different epitopes of the CD20 antigens and have a higher antitumor activity. Engineering techniques can contribute to understanding the effector mechanisms of the application of the novel anti-CD20-MABs and are intended for further improvement of the treatment results.

Keywords: monoclonal antibodies, rituximab, ofatumumab, obinutuzumab, hybridoma technology.

Received: January 13, 2016

Accepted: March 17, 2016

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