non-Hodgkin’s lymphoma

Immune Checkpoint Inhibitors in the Treatment of Lymphomas

REVIEWS , , ,

KV Lepik

RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022

For correspondence: Kirill Viktorovich Lepik, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022; e-mail: lepikkv@gmail.com

For citation: Lepik KV. Immune Checkpoint Inhibitors in the Treatment of Lymphomas. Clinical oncohematology. 2018;11(4):303–12.

DOI: 10.21320/2500-2139-2018-11-4-303-312

ABSTRACT

Programmed death receptors and ligands (PD-1 and PD-L1) are the best studied immune checkpoints (ICP) and are considered to be key factors of immune response control. The ability of tumor cells to affect the ICP receptors is one of the principal mechanisms of suppressing antitumor immunity. The development of ICP inhibitors creates an opportunity to control and activate immune response and opens new perspectives for immunotherapy of cancers, including lymphomas. The paper reviews the biological background for the use of ICP inhibitors in the treatment of classical Hodgkin’s and non-Hodgkin’s lymphomas and summarizes the clinical experience of their use. The new approaches for the creation of combination regimens with ICP are also highlighted.

Keywords: immune checkpoints (ICP), PD-1, PD-L1, classical Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, ICP inhibitors.

Received: March 25, 2018

Accepted: July 23, 2018

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Effect of Patients’ Endocrine Status on Effectiveness of Treatment with Rituximab: State of the Art

LYMPHOID TUMORS , , , ,

YuV Komoza1, VA Komoza1, SV Chernavskii2, OA Rukavitsyn2

1 Bryansk Regional Oncology Dispensary, 96 Stanke Dimitrova pr-t, Bryansk, Russian Federation, 241033

2 Academician NN Burdenko Principal Military Clinical Hospital under the Ministry of Defence of the Russian Federation, 3 Gospital’naya pl., Moscow, Russian Federation, 105229

For correspondence: Yuliya Valer’evna Komoza, 96 Stanke Dimitrova pr-t, Bryansk, Russian Federation, 241033; e-mail: smile-32@mail.ru

For citation: Komoza YuV, Komoza VA, Chernavskii SV, Rukavitsyn OA. Effect of Patients’ Endocrine Status on Effectiveness of Treatment with Rituximab: State of the Art. Clinical oncohematology. 2017;10(2):187–90 (In Russ).

DOI: 10.21320/2500-2139-2017-10-2-187-190

ABSTRACT

The non-Hodgkin’s lymphoma morbidity rate is gradually increasing, and its peak is registered in patients aged 45–60 years. At the same time, the world population steadily becomes older. Monoclonal antibodies (Rituximab) have been used in the treatment of patients with CD20-positive lymphomas for more than 20 years. The use of this drug enhanced the effectiveness of the therapy significantly. However, when patients were divided into groups by age and sex, better results were obtained in the group of women over 60 years. The review presents the results of several studies which have analyzed the effectiveness of rituximab-based schemes in patients depending on their sex and age, using different dosages and administration regimens. The article also presents our personal conclusions about the possible causes of the differences in efficacy of the drug in some patient populations. Identification of the causes contributing to the improvement of the effectiveness of rituximab in elderly women may significantly change approaches to the treatment of lymphomas in patients of both sexes.

Keywords: non-Hodgkin’s lymphoma, rituximab, lymphoma therapy effectiveness, gender differences, age differences.

Received: November 30, 2016

Accepted: January 17, 2017

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Magnetic resonance imaging in diagnosis of non-Hodgkin’s lymphomas of the spine with spinal cord compression

CLINICAL PRESENTATION, DIAGNOSIS, AND MANAGEMENT OF LYMPHOID MALIGNANCIES , ,

A.S. Nered, N.V. Kochergina, A.B. Bludov, Ya.A. Zamogilnaya, A.K. Valiyev, K.A. Borzov, and E.R. Musayev

N.N. Blokhin Russian Cancer Research Center, RAMS, Moscow, Russian Federation

ABSTRACT

MRI features of 5 patients with non-Hodgkin’s lymphomas (NHLs) of the spine with spinal cord compression were studied. It was revealed that NHLs of the spine were characterized by the predominantly homogeneous extraosseous component of soft-tissue density tending to spread to the adjacent vertebrae through the ligaments of the spinal column, lytic cortical layer destruction with the «wrap-around» sign, and the geographic pattern within the affected vertebrae. Compression myelopathy was observed in the spinal stenosis greater than 40 % of its anatomic width.

Keywords: non-Hodgkin’s lymphoma, magnetic resonance imaging, spinal cord compression.

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