lymphomas in HIV-infected patients

Lymphomas in HIV-Infected Patients: Literature Review

REVIEWS , , , , , , ,

A.V. Pivnik1, N.V. Seregin2, Yu.G. Parkhomenko3,4, O.A. Tishkevich4, A.M. Kovrigina5, Е.B. Likunov6

1 N.N. Pletnev Moscow Clinical Research Center, Department of Health, Moscow, Russian Federation

2 Moscow Municipal Cancer Dispensary No. 3, Moscow, Russian Federation

3 Research Institute of Human Morphology, RAMS, Moscow, Russian Federation

4 Clinical Infectious Diseases Hospital No. 2, Department of Health, Moscow, Russian Federation

5 Hematology Research Center, RF MH, Moscow, Russian Federation

6 American Medical Center, Moscow, Russian Federation

Address correspondence to: pivnikav@gmail.com

For citation: Pivnik A.V., Seregin N.V., Parkhomenko Yu.G., Tishkevich O.A., Kovrigina A.M., Likunov E.B. Lymphomas in HIV-Infected Patients: Literature Review. Klin. onkogematol. 2014; 7(3): 264–77 (In Russ.).

ABSTRACT

This review presents data on incidence, pathogenesis, diagnosis, and treatment of lymphoid malignancies in HIV-infected patients. Articles published by Russian and foreign authors are being reviewed. The principle role of decreased CD4+ lymphocyte count in development of secondary diseases in HIV patients is emphasized. Data on the structure of death causes in HIV-infected patients published by Russian authors are presented. They demonstrate that lymphoma is the 5th most common death cause (of 6 leading death causes). Hodgkin’s lymphoma in HIV-infected patients is not discussed in the review, because its pathogenesis differs from that of aggressive lymphomas and requires a separate discussion.

Keywords: lymphomas in HIV-infected patients, HIV, AIDS, secondary disorders, death causes, pathogenesis, diagnosis, treatment.

Accepted: May 15, 2014

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Use of rituximab for treatment of HIV-infected patients with hematological disorders

MONOCLONAL ANTIBODY AND HIV INFECTION , ,

A.V. Pivnik

Medical Center «Genotehnology», Moscow, Russian Federation

ABSTRACT

Rituximab (MabThera) is one of the most powerful drug with selective action on B-cells. The drug suppresses the polyclonal antibody response to own antigens in autoimmune diseases. For lymphatic tumors it selectively acts on tumors of B-cells. Rituximab is widely used in the treatment of patients with immune thrombocytopenic purpura, Moshkovich thrombotic thrombocytopenic purpura, autoimmune hemolytic anemia, rheumatoid arthritis, systemic lupus erythematosus, Crohn’s disease and other diseases. This review describes the clinical cases with the mentioned diseases. All of them are infected with HIV at different stages of the disease. The efficacy of the drug and moderate toxicity were illustrated. Indicators of  HIV infection (CD4 count and viral load) were independent of the drug. In general, rituximab demonstrated successful assessment in hematologic HIV-infected patients.

Keywords: rituximab and HIV, ITP, AIHA, TTP, lymphomas in HIV-infected patients.

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